Double Prins Cyclisation Enabled Rapid Access to α,ω‐Hydroxytetrahydropyrans
Abstract: The spiroketal moiety is an important substructure within many biological natural products. One method to access them is via the oxidative cyclisation of a pendant hydroxyl group on to a pre‐formed pyran. However access to such precursors has hitherto been challenging and requires multistep syntheses frequently with considerable protecting group manipulation. Herein we report a novel and high yielding method for the preparation of hydroxydi‐ and hydroxytetra‐hydropyrans, as spiroketal precursors, utilizing a novel double‐Prins cyclisation approach.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Double Prins Cyclisation Enabled Rapid Access to α,ω‐Hydroxytetrahydropyrans ; volume:2022 ; number:40 ; year:2022 ; extent:10
European journal of organic chemistry ; 2022, Heft 40 (2022) (gesamt 10)
- Urheber
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Trevorrow, Jonathan
O'Kearney‐McMullan, Anne
Miller Potucka, Lucie
Dobbs, Adrian P.
- DOI
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10.1002/ejoc.202200810
- URN
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urn:nbn:de:101:1-2022102615270290416911
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:38 MESZ
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Beteiligte
- Trevorrow, Jonathan
- O'Kearney‐McMullan, Anne
- Miller Potucka, Lucie
- Dobbs, Adrian P.
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