Double Prins Cyclisation Enabled Rapid Access to α,ω‐Hydroxytetrahydropyrans

Abstract: The spiroketal moiety is an important substructure within many biological natural products. One method to access them is via the oxidative cyclisation of a pendant hydroxyl group on to a pre‐formed pyran. However access to such precursors has hitherto been challenging and requires multistep syntheses frequently with considerable protecting group manipulation. Herein we report a novel and high yielding method for the preparation of hydroxydi‐ and hydroxytetra‐hydropyrans, as spiroketal precursors, utilizing a novel double‐Prins cyclisation approach.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Double Prins Cyclisation Enabled Rapid Access to α,ω‐Hydroxytetrahydropyrans ; volume:2022 ; number:40 ; year:2022 ; extent:10 ; European journal of organic chemistry ; 2022, Heft 40 (2022) (gesamt 10)

Contributors, Places and Time

• Creator: Trevorrow, Jonathan ; O'Kearney‐McMullan, Anne ; Miller Potucka, Lucie ; Dobbs, Adrian P.

Further information

• DOI: 10.1002/ejoc.202200810
• URN: urn:nbn:de:101:1-2022102615270290416911
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:38 AM CEST