STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC
Abstract: Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy is incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial‐to‐mesenchymal transition (EMT) is associated with immune evasion and can contribute to immunotherapy resistance. Here, the involvement of STAM Binding Protein Like 1 (STAMBPL1) is reported in the development of mesenchymal and immune evasion phenotypes in KIRC cells. Mechanistically, STAMBPL1 elevated protein abundance and surface accumulation of TAM Receptor AXL through diminishing the TRIM21‐mediated K63‐linked ubiquitination and subsequent lysosomal degradation of AXL, thereby enhancing the expression of mesenchymal genes while suppressing chemokines CXCL9/10 and HLA/B/C. In addition, STAMBPL1 enhanced PD‐L1 transcription via facilitating nuclear translocation of p65, and knockdown (KD) of STAMBPL1 augmented antitumor effects of PD‐1 blockade. Furthermore, STAMBPL1 silencing and the tyrosine kinase inhibitor (TKI) sunitinib also exhibited a synergistic effect on the suppression of KIRC. Collectively, targeting the STAMBPL1/TRIM21/AXL axis can decrease mesenchymal phenotype and potentiate anti‐tumor efficacy of cancer therapy.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC ; day:11 ; month:11 ; year:2024 ; extent:23
Advanced science ; (11.11.2024) (gesamt 23)
- Creator
-
Huang, Shiyu
Qin, Xuke
Fu, Shujie
Hu, Juncheng
Jiang, Zhengyu
Hu, Min
Zhang, Banghua
Liu, Jiachen
Chen, Yujie
Wang, Minghui
Liu, Xiuheng
Chen, Zhiyuan
Wang, Lei
- DOI
-
10.1002/advs.202405083
- URN
-
urn:nbn:de:101:1-2411121313596.496553563745
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:20 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Huang, Shiyu
- Qin, Xuke
- Fu, Shujie
- Hu, Juncheng
- Jiang, Zhengyu
- Hu, Min
- Zhang, Banghua
- Liu, Jiachen
- Chen, Yujie
- Wang, Minghui
- Liu, Xiuheng
- Chen, Zhiyuan
- Wang, Lei
Other Objects (12)
Research and application of land illegal behavior monitoring based on video image recognition
Language proficiency and immigrants’ economic integration
Costs of productivity loss due to occupational cancer in Canada: Estimation using claims data from Workers' Compensation Boards
The Relative Importance of Clinical, Economic, Patient Values and Feasibility Criteria in Cancer Drug Reimbursement in Canada: A Revealed Preferences Analysis of Recommendations of the Pan-Canadian Oncology Drug Review 2011–2017
Measurement report: Water diffusion in single suspended phase-separated aerosols
Multi-classifier ensemble based on dynamic weights
Hospital management practices in county-level hospitals in rural China and international comparison
Riemann problem for a compressible perfect fluid with a constant external force for the Chaplygin gas
Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus
Modelling local bending stiffness based on fibre orientation in sawn timber
Volatility measurement of atmospheric submicron aerosols in an urban atmosphere in southern China
Volatility measurement of atmospheric submicron aerosols in an urban atmosphere in southern China
Research and application of land illegal behavior monitoring based on video image recognition
Language proficiency and immigrants’ economic integration
Costs of productivity loss due to occupational cancer in Canada: Estimation using claims data from Workers' Compensation Boards
The Relative Importance of Clinical, Economic, Patient Values and Feasibility Criteria in Cancer Drug Reimbursement in Canada: A Revealed Preferences Analysis of Recommendations of the Pan-Canadian Oncology Drug Review 2011–2017
Measurement report: Water diffusion in single suspended phase-separated aerosols
Multi-classifier ensemble based on dynamic weights
Hospital management practices in county-level hospitals in rural China and international comparison
Riemann problem for a compressible perfect fluid with a constant external force for the Chaplygin gas
Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus
Modelling local bending stiffness based on fibre orientation in sawn timber
Volatility measurement of atmospheric submicron aerosols in an urban atmosphere in southern China
Volatility measurement of atmospheric submicron aerosols in an urban atmosphere in southern China
Research and application of land illegal behavior monitoring based on video image recognition
Language proficiency and immigrants’ economic integration
Costs of productivity loss due to occupational cancer in Canada: Estimation using claims data from Workers' Compensation Boards
The Relative Importance of Clinical, Economic, Patient Values and Feasibility Criteria in Cancer Drug Reimbursement in Canada: A Revealed Preferences Analysis of Recommendations of the Pan-Canadian Oncology Drug Review 2011–2017
Measurement report: Water diffusion in single suspended phase-separated aerosols
Multi-classifier ensemble based on dynamic weights
Hospital management practices in county-level hospitals in rural China and international comparison
Riemann problem for a compressible perfect fluid with a constant external force for the Chaplygin gas
Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus
Modelling local bending stiffness based on fibre orientation in sawn timber
Volatility measurement of atmospheric submicron aerosols in an urban atmosphere in southern China