The interaction of blood proteins and platelets on surface-attached poly (alkylacrylamide) networks : = Die Wechselwirkung von Blutproteinen und Blutplättchen mit oberflächengebundenen Poly(alkylacrylamid)-Netzwerken

Hochschulschrift

Zusammenfassung: We investigated blood protein adsorption and platelet adhesion onto the surface-attached poly (alkylacrylamide) networks that exhibit small, systematic variations of the chemical composition. The polymer coatings were generated by depositing a thin layer of benzophenone group containing copolymer onto a solid substrate, followed by photo crosslinking and simultaneous surface-attachment. These surface-attached networks showed anisotropic swelling that strongly depended on length of the alkyl substituent. A strong correlation between swelling and protein adsorption was observed. The swollen surface-attached layers were found to repel proteins both through entropic shielding or size exclusion and as a consequence repel blood platelets and cells. Our results suggest that the protein repellent coated materials were promising candidates for the generation of hemocompatible surfaces

Object Details

• Alternative title: Die Wechselwirkung von Blutproteinen und Blutplättchen mit oberflächengebundenen Poly(alkylacrylamid)-Netzwerken
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Albert-Ludwigs-Universität Freiburg, Dissertation, 2013

Classification and Topics

• Keyword: Polymeres Netzwerk ; Polymere ; Thrombozytenadhäsion ; Fibroblast ; Fibrinogen ; Online-Ressource ; Arzneimittelentwicklung ; Arzneimitteldesign

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2013
• Creator: Pandiyarajan, Chinnayan Kannan
• Contributor: Rühe, Jürgen

Further information

• URN: urn:nbn:de:bsz:25-opus-89712
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 13.03.2025, 1:56 PM CET