Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering

Abstract: Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Materials. - 9, 7 (2016) , 560, ISSN: 1996-1944

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2019
Contributor
Institute for Macromolecular Chemistry, Walther Lab

DOI
10.3390/ma9070560
URN
urn:nbn:de:bsz:25-freidok-1372626
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:52 PM CET

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Associated

Time of origin

  • 2019

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