Perinatal development of innate immune topology
Abstract: At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes in cellular immunity. These changes are in part immune cell intrinsic, originate in the replacement of fetal cells, or result from global regulatory mechanisms and adaptation to changes in the tissue microenvironment. Overall, longer developmental trajectories are intersected by events related to mother-infant separation, birth cues, acquisition of microbiota and metabolic factors. Perinatal alterations particularly affect immune niches, where structures with discrete functions meet, the intestinal mucosa, epidermis and lung. Accordingly, the following questions will be addressed in this review:
How does the preprogrammed development supported by endogenous cues, steer innate immune cell differentiation, adaptation to tissue structures, and immunity to infection?
How does the transition at birth impact on tissue immune make-up including its topology?
How do postnatal cues guide innate immune cell differentiation and function at immunological niches?
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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eLife. - 10 (2021) , e67793, ISSN: 2050-084X
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
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Henneke, Philipp
Kierdorf, Katrin
Hall, Lindsay
Sperandio, Markus
Hornef, Mathias
- DOI
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10.7554/eLife.67793
- URN
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urn:nbn:de:bsz:25-freidok-2188569
- Rechteinformation
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:48 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Henneke, Philipp
- Kierdorf, Katrin
- Hall, Lindsay
- Sperandio, Markus
- Hornef, Mathias
- Universität
Entstanden
- 2021
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