The Pleiades are a cluster of fungal effectors that inhibit host defenses
Abstract: Biotrophic plant pathogens secrete effector proteins to manipulate the host physiology. Effectors suppress defenses and induce an environment favorable to disease development. Sequence-based prediction of effector function is impeded by their rapid evolution rate. In the maize pathogen Ustilago maydis, effector-coding genes frequently organize in clusters. Here we describe the functional characterization of the pleiades, a cluster of ten effector genes, by analyzing the micro- and macroscopic phenotype of the cluster deletion and expressing these proteins in planta. Deletion of the pleiades leads to strongly impaired virulence and accumulation of reactive oxygen species (ROS) in infected tissue. Eight of the Pleiades suppress the production of ROS upon perception of pathogen associated molecular patterns (PAMPs). Although functionally redundant, the Pleiades target different host components. The paralogs Taygeta1 and Merope1 suppress ROS production in either the cytoplasm or nucleus, respectively. Merope1 targets and promotes the auto-ubiquitination activity of RFI2, a conserved family of E3 ligases that regulates the production of PAMP-triggered ROS burst in plants
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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PLOS pathogens. - 17, 6 (2021) , e1009641, ISSN: 1553-7374
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2024
- Urheber
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Navarrete, Fernando
Grujic, Nenad
Stirnberg, Alexandra
Saado, Indira
Aleksza, David
Gallei, Michelle
Adi, Hazem
Alcântara, André
Khan, Mamoona
Bindics, János
Trujillo, Marco
Djamei, Armin
- DOI
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10.1371/journal.ppat.1009641
- URN
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urn:nbn:de:bsz:25-freidok-2478652
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:43 MEZ
Datenpartner
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Beteiligte
- Navarrete, Fernando
- Grujic, Nenad
- Stirnberg, Alexandra
- Saado, Indira
- Aleksza, David
- Gallei, Michelle
- Adi, Hazem
- Alcântara, André
- Khan, Mamoona
- Bindics, János
- Trujillo, Marco
- Djamei, Armin
- Universität
Entstanden
- 2024
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