A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling
Abstract: Osteoclasts are bone‐resorbing polykaryons responsible for skeletal remodeling during health and disease. Coincident with their differentiation from myeloid precursors, osteoclasts undergo extensive transcriptional and metabolic reprogramming in order to acquire the cellular machinery necessary to demineralize bone and digest its interwoven extracellular matrix. While attempting to identify new regulatory molecules critical to bone resorption, we discovered that murine and human osteoclast differentiation is accompanied by the expression of Zeb1, a zinc‐finger transcriptional repressor whose role in normal development is most frequently linked to the control of epithelial‐mesenchymal programs. However, following targeting, we find that Zeb1 serves as an unexpected regulator of osteoclast energy metabolism. In vivo, Zeb1‐null osteoclasts assume a hyperactivated state, markedly decreasing bone density due to excessive resorptive activity. Mechanistically, Zeb1 acts in a rheostat‐like fashion to modulate murine and human osteoclast activity by transcriptionally repressing an ATP‐buffering enzyme, mitochondrial creatine kinase 1 (MtCK1), thereby controlling the phosphocreatine energy shuttle and mitochondrial respiration. Together, these studies identify a novel Zeb1/MtCK1 axis that exerts metabolic control over bone resorption in vitro and in vivo.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling ; day:27 ; month:02 ; year:2023 ; extent:23
The EMBO journal / European Molecular Biology Organization ; (27.02.2023) (gesamt 23)
- Creator
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Zhu, Lingxin
Tang, Yi
Li, Xiao‐Yan
Kerk, Samuel A.
Lyssiotis, Costas A.
Feng, Wenqing
Sun, Xiaoyue
Hespe, Geoffrey E.
Wang, Zijun
Stemmler, Marc
Brabletz, Simone
Brabletz, Thomas
Keller, Evan T.
Ma, Jun
Cho, Jung‐Sun
Yang, Jingwen
Weiss, Stephen J.
- DOI
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10.15252/embj.2022111148
- URN
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urn:nbn:de:101:1-2023022714132391299064
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:02 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhu, Lingxin
- Tang, Yi
- Li, Xiao‐Yan
- Kerk, Samuel A.
- Lyssiotis, Costas A.
- Feng, Wenqing
- Sun, Xiaoyue
- Hespe, Geoffrey E.
- Wang, Zijun
- Stemmler, Marc
- Brabletz, Simone
- Brabletz, Thomas
- Keller, Evan T.
- Ma, Jun
- Cho, Jung‐Sun
- Yang, Jingwen
- Weiss, Stephen J.
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