Photochemical Asymmetric Nickel‐Catalyzed Acyl Cross‐Coupling
Abstract: Photochemical enantioselective nickel‐catalyzed cross‐coupling reactions are difficult to implement. We report a visible‐light‐mediated strategy that successfully couples symmetrical anhydrides and 4‐alkyl dihydropyridines (DHPs) to afford enantioenriched α‐substituted ketones under mild conditions. The chemistry does not require exogenous photocatalysts. It is triggered by the direct excitation of DHPs, which act as a radical source and as a reductant, facilitating the turnover of the chiral catalytic nickel complex.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Photochemical Asymmetric Nickel‐Catalyzed Acyl Cross‐Coupling ; volume:58 ; number:47 ; year:2019 ; pages:16854-16858 ; extent:5
Angewandte Chemie / International edition. International edition ; 58, Heft 47 (2019), 16854-16858 (gesamt 5)
- Creator
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Gandolfo, Eugenio
Tang, Xinjun
Raha Roy, Sudipta
Melchiorre, Paolo
- DOI
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10.1002/anie.201910168
- URN
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urn:nbn:de:101:1-2022071211050144390802
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
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Associated
- Gandolfo, Eugenio
- Tang, Xinjun
- Raha Roy, Sudipta
- Melchiorre, Paolo
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