Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia

Abstract: Searching for a peripheral biological marker for schizophrenia, we previously reported on elevated mitochondrial complex I 75-kDa subunit mRNA-blood concentrations in early onset schizophrenia (EOS). The aim of this study was to further evaluate the utility of this gene as a potential marker for schizophrenia. Both—schizophrenia and autism—are suggested to be neuronal maldevelopmental disorders with reports of mitochondrial dysfunction and increased oxidative stress. Therefore we have investigated the expression levels of mitochondrial complex I 75-kDa subunit mRNA in whole blood of children with autistic spectrum disorder (ASD) and a group of adolescent acute first-episode EOS patients in comparison to matched controls. We have found that compared to the respective controls only the group of EOS patients—and not the ASD group—showed a significantly altered expression of the complex I 75-kDa subunit mRNA. Although further studies are necessary to test for the specificity of this ma

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Postprint
begutachtet (peer reviewed)
In: European Child & Adolescent Psychiatry ; 19 (2009) 5 ; 441-448

Ereignis
Veröffentlichung
(wo)
Mannheim
(wann)
2009
Urheber
Taurines, Regina
Thome, Johannes
Duvigneau, J. Catharina
Forbes-Robertson, Sarah
Yang, Liya
Klampfl, Karin
Romanos, Jasmin
Müller, Sabine
Gerlach, Manfred
Mehler-Wex, Claudia

DOI
10.1007/s00787-009-0074-z
URN
urn:nbn:de:0168-ssoar-262310
Rechteinformation
Open Access unbekannt; Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:52 MEZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.

Beteiligte

  • Taurines, Regina
  • Thome, Johannes
  • Duvigneau, J. Catharina
  • Forbes-Robertson, Sarah
  • Yang, Liya
  • Klampfl, Karin
  • Romanos, Jasmin
  • Müller, Sabine
  • Gerlach, Manfred
  • Mehler-Wex, Claudia

Entstanden

  • 2009

Ähnliche Objekte (12)