Multiple sclerosis: Immunopathological heterogeneity and its implications
Abstract: MS is the most common autoimmune demyelinating disease of the CNS. For the past decades, several immunomodulatory disease‐modifying treatments with multiple presumed mechanisms of action have been developed, but MS remains an incurable disease. Whereas high efficacy, at least in early disease, corroborates underlying immunopathophysiology, there is profound heterogeneity in clinical presentation as well as immunophenotypes that may also vary over time. In addition, functional plasticity in the immune system as well as in the inflamed CNS further contributes to disease heterogeneity. In this review, we will highlight immune‐pathophysiological and associated clinical heterogeneity that may have an implication for more precise immunomodulatory therapeutic strategies in MS.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Multiple sclerosis: Immunopathological heterogeneity and its implications ; day:06 ; month:05 ; year:2022 ; extent:13
European journal of immunology ; (06.05.2022) (gesamt 13)
- Urheber
- DOI
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10.1002/eji.202149757
- URN
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urn:nbn:de:101:1-2022050715072732768661
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Engelhardt, Britta
- Comabella, Manuel
- Chan, Andrew
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