Multiple sclerosis: Immunopathological heterogeneity and its implications
Abstract: MS is the most common autoimmune demyelinating disease of the CNS. For the past decades, several immunomodulatory disease‐modifying treatments with multiple presumed mechanisms of action have been developed, but MS remains an incurable disease. Whereas high efficacy, at least in early disease, corroborates underlying immunopathophysiology, there is profound heterogeneity in clinical presentation as well as immunophenotypes that may also vary over time. In addition, functional plasticity in the immune system as well as in the inflamed CNS further contributes to disease heterogeneity. In this review, we will highlight immune‐pathophysiological and associated clinical heterogeneity that may have an implication for more precise immunomodulatory therapeutic strategies in MS.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Multiple sclerosis: Immunopathological heterogeneity and its implications ; day:06 ; month:05 ; year:2022 ; extent:13
European journal of immunology ; (06.05.2022) (gesamt 13)
- Creator
- DOI
-
10.1002/eji.202149757
- URN
-
urn:nbn:de:101:1-2022050715072732768661
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Engelhardt, Britta
- Comabella, Manuel
- Chan, Andrew
Other Objects (12)
Heterogeneity of multiple sclerosis lesions in multislice myelin water imaging
R&D Heterogeneity and Its Implications for Growth
Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms
Multiple sclerosis
Multiple sclerosis
Update on multiple sclerosis, its diagnosis and treatments
Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions
Heterogeneity in macroeconomics and its implications for monetary policy
The hidden heterogeneity of inflation expectations and its implications
Pediatric Multiple Sclerosis
Heterogeneity of Patenting Activity and Its Implications for Scientific Research
Heterogeneity of Patenting Activity and Its Implications for Scientific Research
Heterogeneity of multiple sclerosis lesions in multislice myelin water imaging
R&D Heterogeneity and Its Implications for Growth
Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms
Multiple sclerosis
Multiple sclerosis
Update on multiple sclerosis, its diagnosis and treatments
Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions
Heterogeneity in macroeconomics and its implications for monetary policy
The hidden heterogeneity of inflation expectations and its implications
Pediatric Multiple Sclerosis
Heterogeneity of Patenting Activity and Its Implications for Scientific Research
Heterogeneity of Patenting Activity and Its Implications for Scientific Research
Heterogeneity of multiple sclerosis lesions in multislice myelin water imaging
R&D Heterogeneity and Its Implications for Growth
Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms
Multiple sclerosis
Multiple sclerosis
Update on multiple sclerosis, its diagnosis and treatments
Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions
Heterogeneity in macroeconomics and its implications for monetary policy
The hidden heterogeneity of inflation expectations and its implications
Pediatric Multiple Sclerosis
Heterogeneity of Patenting Activity and Its Implications for Scientific Research