Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants
Abstract: Obesity is one of the most important health risks in postmenopausal women. Molecular pathways that are connected with obesity are believed to interact with the pathogenesis of breast cancer (BC). The aim of this research was to study the polymorphisms of two obesity-associated genes ADIPOQ and FTO that are also related to the pathogenesis of BC. Obesity-associated gene polymorphisms ADIPOQ rs1501299 and rs2241766, and FTO rs1477196, rs7206790, rs8047395, and rs9939609 were studied in 101 Turkish postmenopausal estrogen receptor-positive BC patients and 100 healthy control individuals. ADIPOQ rs1501299 was detected to be associated with protection against BC. The ADIPOQ rs1501299 TT genotype, the rs2241766 GT genotype and the G allele were found to be significantly higher in the control group. In addition, ADIPOQ rs1501299 polymorphism was protective in the recessive model and rs2241766 polymorphism was protective in the dominant model. While none of the FTO gene polymorphisms were .... https://www.excli.de/index.php/excli/article/view/2860
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants ; volume:20 ; day:05 ; month:07 ; year:2021
EXCLI journal ; 20 (05.07.2021)
- Urheber
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Özgöz, Asuman
Mutlu İçduygu, Fadime
Yükseltürk, Ayşegül
Şamli, Hale
Hekimler Öztürk, Kuyaş
Başkan, Zuhal
Tütüncü †, İlknur
- DOI
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10.17179/excli2020-2860
- URN
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urn:nbn:de:101:1-2021091010490911488785
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
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Beteiligte
- Özgöz, Asuman
- Mutlu İçduygu, Fadime
- Yükseltürk, Ayşegül
- Şamli, Hale
- Hekimler Öztürk, Kuyaş
- Başkan, Zuhal
- Tütüncü †, İlknur
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