Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants

Abstract: Obesity is one of the most important health risks in postmenopausal women. Molecular pathways that are connected with obesity are believed to interact with the pathogenesis of breast cancer (BC). The aim of this research was to study the polymorphisms of two obesity-associated genes ADIPOQ and FTO that are also related to the pathogenesis of BC. Obesity-associated gene polymorphisms ADIPOQ rs1501299 and rs2241766, and FTO rs1477196, rs7206790, rs8047395, and rs9939609 were studied in 101 Turkish postmenopausal estrogen receptor-positive BC patients and 100 healthy control individuals. ADIPOQ rs1501299 was detected to be associated with protection against BC. The ADIPOQ rs1501299 TT genotype, the rs2241766 GT genotype and the G allele were found to be significantly higher in the control group. In addition, ADIPOQ rs1501299 polymorphism was protective in the recessive model and rs2241766 polymorphism was protective in the dominant model. While none of the FTO gene polymorphisms were .... https://www.excli.de/index.php/excli/article/view/2860

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants ; volume:20 ; day:05 ; month:07 ; year:2021 ; EXCLI journal ; 20 (05.07.2021)

Contributors, Places and Time

• Creator: Özgöz, Asuman ; Mutlu İçduygu, Fadime ; Yükseltürk, Ayşegül ; Şamli, Hale ; Hekimler Öztürk, Kuyaş ; Başkan, Zuhal ; Tütüncü †, İlknur

Further information

• DOI: 10.17179/excli2020-2860
• URN: urn:nbn:de:101:1-2021091010490911488785
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST