Electrosynthesis of Quinoxalines via Intermolecular Cyclization/Dehydrogenation of Ketones with o-Phenylenediamines
In this study, we proposed a novel electrochemical dehydrogenative synthetic method for preparing 2-substituted quinoxalines by intermolecular cyclization of aryl alkyl ketones and o-phenylenediamines. This method gave various quinoxalines in yields ranging from 35% to 71%. This novel protocol employs mild reaction conditions and offers moderate to excellent yields, a wide substrate scope, and broad functional-group compatibility. Furthermore, a late-stage functionalization and the wide substrate scope demonstrated the synthetic utility of this protocol.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Electrosynthesis of Quinoxalines via Intermolecular Cyclization/Dehydrogenation of Ketones with o-Phenylenediamines ; day:14 ; month:06 ; year:2024
Synlett ; (14.06.2024)
- Contributor
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Tao, Yi
Zhang, Jiahui
Hu, Yangyang
Liu, Huiying
Sun, Jingwen
Liu, Lei
- DOI
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10.1055/a-2339-2832
- URN
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urn:nbn:de:101:1-2408221143184.154721649207
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:45 AM CEST
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Associated
- Tao, Yi
- Zhang, Jiahui
- Hu, Yangyang
- Liu, Huiying
- Sun, Jingwen
- Liu, Lei
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Intermolecular Photoredox Coupling: Alternative to Norrish Type II Reaction and Yang Cyclization in Ketones with γ‐C−H Bonds
Dual-Catalysed Intermolecular Reductive Coupling of Dienes and Ketones
Dual‐Catalysed Intermolecular Reductive Coupling of Dienes and Ketones **
Ruthenium‐Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism
Ruthenium‐Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism
Aza‐Prins Cyclization on Ketones to Access Piperidines with Tetrasubstituted Carbon Stereocenters
Copper hydride catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes
Preparation of Large Perphenylbiaryls: Can Intermolecular Coupling Compete with Intramolecular Cyclization of Precursors?
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Intermolecular Photoredox Coupling: Alternative to Norrish Type II Reaction and Yang Cyclization in Ketones with γ‐C−H Bonds
Dual-Catalysed Intermolecular Reductive Coupling of Dienes and Ketones
Dual‐Catalysed Intermolecular Reductive Coupling of Dienes and Ketones **
Ruthenium‐Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism
Ruthenium‐Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism
Aza‐Prins Cyclization on Ketones to Access Piperidines with Tetrasubstituted Carbon Stereocenters
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Preparation of Large Perphenylbiaryls: Can Intermolecular Coupling Compete with Intramolecular Cyclization of Precursors?
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