Molecular Tuning of a Benzene‐1,3,5‐Tricarboxamide Supramolecular Fibrous Hydrogel Enables Control over Viscoelasticity and Creates Tunable ECM‐Mimetic Hydrogels and Bioinks

Abstract: Traditional synthetic covalent hydrogels lack the native tissue dynamics and hierarchical fibrous structure found in the extracellular matrix (ECM). These dynamics and fibrous nanostructures are imperative in obtaining the correct cell/material interactions. Consequently, the challenge to engineer functional dynamics in a fibrous hydrogel and recapitulate native ECM properties remains a bottle‐neck to biomimetic hydrogel environments. Here, the molecular tuning of a supramolecular benzene‐1,3,5‐tricarboxamide (BTA) hydrogelator via simple modulation of hydrophobic substituents is reported. This tuning results in fibrous hydrogels with accessible viscoelasticity over 5 orders of magnitude, while maintaining a constant equilibrium storage modulus. BTA hydrogelators are created with systematic variations in the number of hydrophobic carbon atoms, and this is observed to control the viscoelasticity and stress‐relaxation timescales in a logarithmic fashion. Some of these BTA hydrogels are shear‐thinning, self‐healing, extrudable, and injectable, and can be 3D printed into multiple layers. These hydrogels show high cell viability for chondrocytes and human mesenchymal stem cells, establishing their use in tissue engineering applications. This simple molecular tuning by changing hydrophobicity (with just a few carbon atoms) provides precise control over the viscoelasticity and 3D printability in fibrillar hydrogels and can be ported onto other 1D self‐assembling structures. The molecular control and design of hydrogel network dynamics can push the field of supramolecular chemistry toward the design of new ECM‐mimicking hydrogelators for numerous cell‐culture and tissue‐engineering applications and give access toward highly biomimetic bioinks for bioprinting.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Molecular Tuning of a Benzene‐1,3,5‐Tricarboxamide Supramolecular Fibrous Hydrogel Enables Control over Viscoelasticity and Creates Tunable ECM‐Mimetic Hydrogels and Bioinks ; day:28 ; month:04 ; year:2023 ; extent:17
Advanced materials ; (28.04.2023) (gesamt 17)

Urheber
Hafeez, Shahzad
Aldana, Ana A.
Duimel, Hans
Ruiter, Floor A. A.
Decarli, Monize Caiado
Lapointe, Vanessa
van Blitterswijk, Clemens
Moroni, Lorenzo
Baker, Matthew B.

DOI
10.1002/adma.202207053
URN
urn:nbn:de:101:1-2023042915151829243529
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 11:00 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.

Beteiligte

  • Hafeez, Shahzad
  • Aldana, Ana A.
  • Duimel, Hans
  • Ruiter, Floor A. A.
  • Decarli, Monize Caiado
  • Lapointe, Vanessa
  • van Blitterswijk, Clemens
  • Moroni, Lorenzo
  • Baker, Matthew B.

Ähnliche Objekte (12)