Applications of the Reversible Boronic Acids/Boronate Switch to Nucleic Acids
Abstract: Over the last decades, boron and nucleic acids chemistries have gained a lot of attention for biological, medicinal and analytical applications. Our laboratory has a long‐standing interest in both chemistries and owing to the ability of boronic acids to react with cis‐diol function in aqueous media we developed over the years a variety of applications ranging from molecular recognition and sensing to the development of reversible dynamic systems in which the natural phosphodiester linkage was replaced by a boronate. In this account, we summarize research results from our group from our preliminary studies on molecular recognition of ribonucleosides to the dynamic assembly of functional DNAzymes. In particular, the various parameters influencing the dynamic nature of these reversible covalent bonds able to respond to external stimuli are discussed. Finally, current challenges and opportunities for boron‐based nucleic acids are also addressed.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Applications of the Reversible Boronic Acids/Boronate Switch to Nucleic Acids ; day:31 ; month:05 ; year:2022 ; extent:1
The chemical record ; (31.05.2022) (gesamt 1)
- Urheber
-
Debiais, Mégane
Vasseur, Jean‐Jacques
Smietana, Michael
- DOI
-
10.1002/tcr.202200085
- URN
-
urn:nbn:de:101:1-2022060115121684291872
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:24 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Debiais, Mégane
- Vasseur, Jean‐Jacques
- Smietana, Michael
Ähnliche Objekte (12)
Boronic acid assisted assembly and activity control of split nucleic acid enzymes
Boronic acids, Vol. 2.
Boronic acids, Vol. 1.
Reversible Self‐Assembly of Nucleic Acids in a Diffusiophoretic Trap
Synthesis of Anilines from Boronic Acids
Boronic Acid Catalyzed Dehydrative Peptide Synthesis
Nucleic acid nanotechnology
Quadruplex nucleic acids
Extracellular nucleic acids
Nucleic acid chemistry
Orthogonal Nucleic Acids
Nucleic acid polymerases
Boronic acid assisted assembly and activity control of split nucleic acid enzymes
Boronic acids, Vol. 2.
Boronic acids, Vol. 1.
Reversible Self‐Assembly of Nucleic Acids in a Diffusiophoretic Trap
Synthesis of Anilines from Boronic Acids
Boronic Acid Catalyzed Dehydrative Peptide Synthesis
Nucleic acid nanotechnology
Quadruplex nucleic acids
Extracellular nucleic acids
Nucleic acid chemistry
Orthogonal Nucleic Acids
Nucleic acid polymerases
Boronic acid assisted assembly and activity control of split nucleic acid enzymes
Boronic acids, Vol. 2.
Boronic acids, Vol. 1.
Reversible Self‐Assembly of Nucleic Acids in a Diffusiophoretic Trap
Synthesis of Anilines from Boronic Acids
Boronic Acid Catalyzed Dehydrative Peptide Synthesis
Nucleic acid nanotechnology
Quadruplex nucleic acids
Extracellular nucleic acids
Nucleic acid chemistry
Orthogonal Nucleic Acids