The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion
Abstract: Signals delivered by costimulatory molecules are implicated in driving T cell expansion. The requirements for these signals, however, vary from dispensable to essential in different infections. We examined the underlying mechanisms of this differential T cell costimulation dependence and found that the viral context determined the dependence on CD28/B7-mediated costimulation for expansion of naive and memory CD8+ T cells, indicating that the requirement for costimulatory signals is not imprinted. Notably, related to the high-level costimulatory molecule expression induced by lymphocytic choriomeningitis virus (LCMV), CD28/B7-mediated costimulation was dispensable for accumulation of LCMV-specific CD8+ T cells because of redundancy with the costimulatory pathways induced by TNF receptor family members (i.e., CD27, OX40, and 4-1BB). Type I IFN signaling in viral-specific CD8+ T cells is slightly redundant with costimulatory signals. These results highlight that pathogen-specific conditions differentially and uniquely dictate the utilization of costimulatory pathways allowing shaping of effector and memory antigen-specific CD8+ T cell responses
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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eLife. - 4 (2015) , e07486, ISSN: 2050-084X
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2019
- Creator
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Welten, Suzanne P. M.
Redeker, Anke
Franken, Kees L. M. C
Oduro, Jennifer Dora
Ossendorp, Ferry
Cicin-Sain, Luka
Melief, Cornelis J. M
Aichele, Peter
Arens, Ramon
- Contributor
- DOI
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10.7554/elife.07486
- URN
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urn:nbn:de:bsz:25-freidok-1274415
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:46 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Welten, Suzanne P. M.
- Redeker, Anke
- Franken, Kees L. M. C
- Oduro, Jennifer Dora
- Ossendorp, Ferry
- Cicin-Sain, Luka
- Melief, Cornelis J. M
- Aichele, Peter
- Arens, Ramon
- Institut für Immunologie. Freiburg im Breisgau
- Universität
Time of origin
- 2019