Personalized PLGA/BCL Scaffold with Hierarchical Porous Structure Resembling Periosteum‐Bone Complex Enables Efficient Repair of Bone Defect
Abstract: Using bone regeneration scaffolds to repair craniomaxillofacial bone defects is a promising strategy. However, most bone regeneration scaffolds still exist some issues such as a lack of barrier structure, inability to precisely match bone defects, and necessity to incorporate biological components to enhance efficacy. Herein, inspired by a periosteum‐bone complex, a class of multifunctional hierarchical porous poly (lactic‐co‐glycolic acid)/baicalein scaffolds is facilely prepared by the union of personalized negative mold technique and phase separation strategy and demonstrated to precisely fit intricate bone defect cavity. The dense up‐surface of the scaffold can prevent soft tissue cell penetration, while the loose bottom‐surface can promote protein adsorption, cell adhesion, and cell infiltration. The interior macropores of the scaffold and the loaded baicalein can synergistically promote cell differentiation, angiogenesis, and osteogenesis. These findings can open an appealing avenue for the development of personalized multifunctional hierarchical materials for bone repair.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Personalized PLGA/BCL Scaffold with Hierarchical Porous Structure Resembling Periosteum‐Bone Complex Enables Efficient Repair of Bone Defect ; day:17 ; month:07 ; year:2024 ; extent:11
Advanced science ; (17.07.2024) (gesamt 11)
- Urheber
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Zhang, Mengqi
Huang, Zhike
Wang, Xun
Liu, Xinyu
He, Wenyi
Li, Yan
Wu, Dingcai
Wu, Shuyi
- DOI
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10.1002/advs.202401589
- URN
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urn:nbn:de:101:1-2407181421336.091915406653
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:01 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhang, Mengqi
- Huang, Zhike
- Wang, Xun
- Liu, Xinyu
- He, Wenyi
- Li, Yan
- Wu, Dingcai
- Wu, Shuyi
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