A[beta] seeding as a tool to study cerebral amyloidosis and associated pathology

to related objects

Abstract: Misfolded proteins can form aggregates and induce a self-perpetuating process leading to the amplification and spreading of pathological protein assemblies. These misfolded protein assemblies act as seeds of aggregation. In an in vivo exogenous seeding model, both the features of seeds and the position at which seeding originates are precisely defined. Ample evidence from studies on intracerebal injection of amyloid-beta (Aβ)-rich brain extracts suggests that Aβ aggregation can be initiated by prion-like seeding. In this mini-review article, we will summarize the past and current literature on Aβ seeding in mouse models of AD and discuss its implementation as a tool to study cerebral amyloidosis and associated pathology

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Frontiers in molecular neuroscience. - 12 (2019) , 233, ISSN: 1662-5099

Keyword: Alzheimerkrankheit
Amyloidose

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2019

Creator: Friesen, Marina
Meyer-Lühmann, Melanie

DOI: 10.3389/fnmol.2019.00233

URN: urn:nbn:de:bsz:25-freidok-1514763

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:57 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Time of origin

2019

Other Objects (12)

Remodeling Alzheimer-amyloidosis models by seeding

Hochschulschrift

Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation

Growth Hormone and Cerebral Amyloidosis

Prion-like aspects of cerebral amyloidosis

A[beta] oligomers trigger and accelerate A[beta] seeding

Konferenzschrift

Pathology of cerebral microcirculation

Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis

Modulation of cerebral β-amyloidosis by myeloid cells

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

TDP-43 pathology is associated with increased tau burdens and seeding

Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Cerebral angiography : normal anatomy and pathology

Remodeling Alzheimer-amyloidosis models by seeding

Hochschulschrift

Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation

Growth Hormone and Cerebral Amyloidosis

Prion-like aspects of cerebral amyloidosis

A[beta] oligomers trigger and accelerate A[beta] seeding

Konferenzschrift

Pathology of cerebral microcirculation

Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis

Modulation of cerebral β-amyloidosis by myeloid cells

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

TDP-43 pathology is associated with increased tau burdens and seeding

Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Cerebral angiography : normal anatomy and pathology

Remodeling Alzheimer-amyloidosis models by seeding

Hochschulschrift

Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation

Growth Hormone and Cerebral Amyloidosis

Prion-like aspects of cerebral amyloidosis

A[beta] oligomers trigger and accelerate A[beta] seeding

Konferenzschrift

Pathology of cerebral microcirculation

Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis

Modulation of cerebral β-amyloidosis by myeloid cells

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

TDP-43 pathology is associated with increased tau burdens and seeding

Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Cerebral angiography : normal anatomy and pathology

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

A[beta] seeding as a tool to study cerebral amyloidosis and associated pathology

Object Details

Classification and Topics

Contributors, Places and Time

Further information

Data provider

Associated

Time of origin

Other Objects (12)

Remodeling Alzheimer-amyloidosis models by seeding

Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation

Growth Hormone and Cerebral Amyloidosis

Prion-like aspects of cerebral amyloidosis

A[beta] oligomers trigger and accelerate A[beta] seeding

Pathology of cerebral microcirculation

Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis

Modulation of cerebral β-amyloidosis by myeloid cells

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

TDP-43 pathology is associated with increased tau burdens and seeding

Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Cerebral angiography : normal anatomy and pathology

Remodeling Alzheimer-amyloidosis models by seeding

Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation

Growth Hormone and Cerebral Amyloidosis

Prion-like aspects of cerebral amyloidosis

A[beta] oligomers trigger and accelerate A[beta] seeding

Pathology of cerebral microcirculation

Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis

Modulation of cerebral β-amyloidosis by myeloid cells

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

TDP-43 pathology is associated with increased tau burdens and seeding

Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Cerebral angiography : normal anatomy and pathology

Remodeling Alzheimer-amyloidosis models by seeding

Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation

Growth Hormone and Cerebral Amyloidosis

Prion-like aspects of cerebral amyloidosis

A[beta] oligomers trigger and accelerate A[beta] seeding

Pathology of cerebral microcirculation

Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis

Modulation of cerebral β-amyloidosis by myeloid cells

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

TDP-43 pathology is associated with increased tau burdens and seeding

Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease

Cerebral angiography : normal anatomy and pathology

Related objects

Reset password