Segmented thermoplastic polyesters, development, characterization and applications

Abstract: The primary aim of this thesis was the development of a molecularly defined biomaterial platform with tunable physicochemical characteristics, which could have wide-ranging applications in biomedical and consumer product space. Toward this goal, a molecular design strategy that combines prominent properties of three well-established polymer systems namely: poly(l-lactic acid) (PLLA), polydimethylsiloxane (PDMS) and fluoropolymers has been developed and a novel class of biomaterials termed Segmented Thermoplastic Polyesters (STEP); that possess thermal and solution processibility, surface inertness, thermal responsiveness, optical transparency, biodegradability, elasticity and cytocompatibility in a single system has been realized. This thesis comprises of 9 chapters. In the first chapter, a literature review is presented including a general introduction to biomaterials and biodegradable polymers, followed by a brief overview of blood-contacting materials, superhydrophobic polymers, responsive smart polymers, and finally polymeric coatings. The second chapter focuses on explaining the aims of the work and design of the material platform and its proposed applications. In the third chapter, synthesis and characterization of responsive and optically transparent STEP polymers are presented. Their cytocompatibility and activatable shape change in the vicinity of human body temperature (37 °C) offer an opportunity for potential medical applications. In chapter 4, the fluorinated segmented thermoplastic polyesters (f.STEP) are presented, and their synthesis, characterization and properties such as bioinertness, processability, and low protein absorption are discussed. The f.STEP polymers can be processed in superhydrophobic electrospun mats with low fibrinogen adsorption that repel water and human blood. These findings make this class of polymers, a suitable choice for blood-contacting and anti-adhesive surfaces. The stretchable STEPs with three different macroinitiator chain lengths are presented in chapter 5, and their activatable wettability change (Δ=15°) and corresponding, time and temperature dependent recovery triggered by IR radiation are investigated. Furthermore, oxygen plasma activation of STEP surface VI Surface Inertness and Hydrophobicity Cytocompatibility STEP Biomaterials Thermal and Solu.on Processibility Thermal Responsiveness Mechanical Flexibility and Biodegradability Optical Transparency Schematic: Key properties of the STEP biomaterials is investigated and successful film bonding is demonstrated. The ability of STEPs to yield microparticles with tunable morphology and their cell interaction and uptake are presented in chapter 6, and few exemplars of biomedical and industrial applications of STEP polymers are explored in chapter 7. Finally, all findings, conclusion and future work are summarized, and discussed in chapter 8, and the experimental details and procedures are presented in chapter 9

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Universität Freiburg, Dissertation, 2019

Classification and Topics

• Keyword: Biomaterial ; Polyester

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2019
• Creator: Matloubigharagozloo, Maziar
• Contributor: Albert-Ludwigs-Universität Freiburg. Fakultät für Chemie und Pharmazie

Further information

• DOI: 10.6094/UNIFR/151192
• URN: urn:nbn:de:bsz:25-freidok-1511922
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:54 PM CET