Vinyl Cation Stabilization by Silicon Enables a Formal Metal‐Free α‐Arylation of Alkyl Ketones
Abstract: The ability of silicon to stabilize vinyl cationic species leads to a redox arylation of alkynes whereby the stringent limitations of reactivity and regioselectivity of alkyl‐substituted alkynes are lifted. This allows the synthesis of a range of α‐silyl‐α′‐arylketones under mild conditions in good to excellent yields and with high functional group tolerance, whereby the silicon moiety in the final products can either be removed for a formal acetone monoarylation transform, or capitalized upon for subsequent electrophilic substitutions at either side of the carbonyl group.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Vinyl Cation Stabilization by Silicon Enables a Formal Metal‐Free α‐Arylation of Alkyl Ketones ; volume:58 ; number:48 ; year:2019 ; pages:17303-17306 ; extent:4
Angewandte Chemie / International edition. International edition ; 58, Heft 48 (2019), 17303-17306 (gesamt 4)
- Urheber
- DOI
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10.1002/anie.201909381
- URN
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urn:nbn:de:101:1-2022080611171111523927
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:29 MESZ
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Beteiligte
- Pons, Amandine
- Michalland, Jean
- Zawodny, Wojciech
- Chen, Yong
- Tona, Veronica
- Maulide, Nuno
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