PILS proteins provide a homeostatic feedback on auxin signaling output
Abstract: Multiple internal and external signals modulate the metabolism, intercellular transport and signaling of the phytohormone auxin. Considering this complexity, it remains largely unknown how plant cells monitor and ensure the homeostasis of auxin responses. PIN-LIKES (PILS) intracellular auxin transport facilitators at the endoplasmic reticulum are suitable candidates to buffer cellular auxin responses because they limit nuclear abundance and signaling of auxin. We used forward genetics to identify gloomy and shiny pils (gasp) mutants that define the PILS6 protein abundance in a post-translational manner. Here, we show that GASP1 encodes an uncharacterized RING/U-box superfamily protein that impacts on auxin signaling output. The low auxin signaling in gasp1 mutants correlates with reduced abundance of PILS5 and PILS6 proteins. Mechanistically, we show that high and low auxin conditions increase and reduce PILS6 protein levels, respectively. Accordingly, non-optimum auxin concentrations are buffered by alterations in PILS6 abundance, consequently leading to homeostatic auxin output regulation. We envision that this feedback mechanism provides robustness to auxin-dependent plant development
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Development. - 149, 13 (2022) , dev200929, ISSN: 1477-9129
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2024
- Urheber
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Feraru, Elena
Feraru, Mugurel I.
Moulinier-Anzola, Jeanette
Schwihla, Maximilian
Ferreira Da Silva Santos, Jonathan
Sun, Lin
Waidmann, Sascha
Korbei, Barbara
Kleine-Vehn, Jürgen
- DOI
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10.1242/dev.200929
- URN
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urn:nbn:de:bsz:25-freidok-2444902
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:51 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Feraru, Elena
- Feraru, Mugurel I.
- Moulinier-Anzola, Jeanette
- Schwihla, Maximilian
- Ferreira Da Silva Santos, Jonathan
- Sun, Lin
- Waidmann, Sascha
- Korbei, Barbara
- Kleine-Vehn, Jürgen
- Universität
Entstanden
- 2024
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