Immunoregulation and antidepressant effect of ketamine
Abstract: Major depressive disorder (MDD) is a common mental health disorder that brings severe disease burden worldwide. Traditional antidepressants are mainly targeted at monoamine neurotransmitters, with low remission rates and high recurrence rates. Ketamine is a noncompetitive glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist, and its rapid and powerful antidepressant effects have come to light. Its antidepressant mechanism is still unclarified. Research found that ketamine had not only antagonistic effect on NMDAR but also strong immunomodulatory effect, both of which were closely related to the pathophysiology of MDD. Although there are many related studies, they are relatively heterogeneous. Therefore, this review mainly describes the immune mechanisms involved in MDD and how ketamine plays an antidepressant role by regulating peripheral and central immune system, including peripheral inflammatory cytokines, central microglia, and astrocytes. This review summarizes the related research, finds out the deficiencies of current research, and provides ideas for future research and the development of novel antidepressants.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Immunoregulation and antidepressant effect of ketamine ; volume:12 ; number:1 ; year:2021 ; pages:218-236 ; extent:19
Translational Neuroscience ; 12, Heft 1 (2021), 218-236 (gesamt 19)
- Urheber
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Zhang, Nan
Yao, Lihua
Wang, Peilin
Liu, Zhongchun
- DOI
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10.1515/tnsci-2020-0167
- URN
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urn:nbn:de:101:1-2022082914435255411074
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:36 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhang, Nan
- Yao, Lihua
- Wang, Peilin
- Liu, Zhongchun
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