Proteomics research of SARS-CoV-2 and COVID-19 disease
Abstract: Currently, coronavirus disease 2019 (COVID-19) is still spreading in a global scale, exerting a massive health and socioeconomic crisis. Deep insights into the molecular functions of the viral proteins and the pathogenesis of this infectious disease are urgently needed. In this review, we comprehensively describe the proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and summarize their protein interaction map with host cells. In the protein interaction network between the virus and the host, a total of 787 host prey proteins that appeared in at least two studies or were verified by co-immunoprecipitation experiments. Together with 29 viral proteins, a network of 1762 proximal interactions were observed. We also review the proteomics results of COVID-19 patients and proved that SARS-CoV-2 hijacked the host’s translation system, post-translation modification system, and energy supply system via viral proteins, resulting in various immune disorders, multiple cardiomyopathies, and cholesterol metabolism diseases.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Proteomics research of SARS-CoV-2 and COVID-19 disease ; volume:2 ; number:4 ; year:2022 ; pages:427-445 ; extent:019
Medical Review ; 2, Heft 4 (2022), 427-445 (gesamt 019)
- Urheber
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Zhang, Nan
Wang, Siyuan
Wong, Catherine C.L.
- DOI
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10.1515/mr-2022-0016
- URN
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urn:nbn:de:101:1-2022100214043607743935
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:33 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhang, Nan
- Wang, Siyuan
- Wong, Catherine C.L.
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