Assessment of heart valve performance by finite-element design studies of polymeric leaflet-structures
Abstract: For the treatment of severe symptomatic aortic valve stenosis, minimally invasive heart valve prostheses are increasingly used, especially for elderly patients. The current generation of devices is based on xenogenic leaflet material, involving limitations with regard to calcification and durability. Artificial polymeric leaflet-structures re-present a promising approach for improvement of valve performance. Within the current work, finite-element ana-lysis (FEA) design studies of polymeric leaflet structures were conducted. Design of an unpressurized and axially-symmetric trileaflet heart valve was developed based on nine parameters. Physiological pressurization in FEA was specified, based on in vitro hydrodynamic testing of a commercially available heart valve prosthesis. Hyper-elastic constitutive law for polymeric leaflet material was implemented based on experimental stress strain curves resulting from uniaxial tensile and planar shear testing. As a result of FEA, time dependent leaflet deformation of the leaflet structure was calculated. Obtained leaflet dynamics were comparable to in vitro performance of the analyzed prosthesis. As a major design parameter, the lunula angle has demonstrated crucial influence on the performance of the polymeric leaflet structures. FEA represented a useful tool for design of improved polymeric leaflet structures for minimally invasive implantable heart valve prostheses.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Assessment of heart valve performance by finite-element design studies of polymeric leaflet-structures ; volume:3 ; number:2 ; year:2017 ; pages:631-634 ; extent:4
Current directions in biomedical engineering ; 3, Heft 2 (2017), 631-634 (gesamt 4)
- Creator
-
Pfensig, Sylvia
Kaule, Sebastian
Sämann, Michael
Stiehm, Michael
Grabow, Niels
Schmitz, Klaus-Peter
Siewert, Stefan
- DOI
-
10.1515/cdbme-2017-0132
- URN
-
urn:nbn:de:101:1-2023030713044827286926
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:53 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Pfensig, Sylvia
- Kaule, Sebastian
- Sämann, Michael
- Stiehm, Michael
- Grabow, Niels
- Schmitz, Klaus-Peter
- Siewert, Stefan
Other Objects (12)
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Transfer activities for cardiovascular, ophthalmologic and otolaryngologic medical device innovations
Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications : Progress report from the Twenty20 consortium RESPONSE
Cardiovascular, ophthalmologic and otolaryngologic medical device innovations – Progress report 2021 from the Twenty20 consortium RESPONSE
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Accelerated Degradation of polymeric surgical suture materials
LIPSS on polymeric implant surfaces - a fabrication study
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
Cell adhesion and viability of human endothelial cells on electrospun polymer scaffolds
Transient Euler-Lagrange/DEM simulation of stent thrombosis
Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Transfer activities for cardiovascular, ophthalmologic and otolaryngologic medical device innovations
Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications : Progress report from the Twenty20 consortium RESPONSE
Cardiovascular, ophthalmologic and otolaryngologic medical device innovations – Progress report 2021 from the Twenty20 consortium RESPONSE
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Accelerated Degradation of polymeric surgical suture materials
LIPSS on polymeric implant surfaces - a fabrication study
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
Cell adhesion and viability of human endothelial cells on electrospun polymer scaffolds
Transient Euler-Lagrange/DEM simulation of stent thrombosis
Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Transfer activities for cardiovascular, ophthalmologic and otolaryngologic medical device innovations
Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications : Progress report from the Twenty20 consortium RESPONSE
Cardiovascular, ophthalmologic and otolaryngologic medical device innovations – Progress report 2021 from the Twenty20 consortium RESPONSE
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Accelerated Degradation of polymeric surgical suture materials
LIPSS on polymeric implant surfaces - a fabrication study
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
Cell adhesion and viability of human endothelial cells on electrospun polymer scaffolds
Transient Euler-Lagrange/DEM simulation of stent thrombosis