Assessment of heart valve performance by finite-element design studies of polymeric leaflet-structures

zu Verbundenen Objekten

Abstract: For the treatment of severe symptomatic aortic valve stenosis, minimally invasive heart valve prostheses are increasingly used, especially for elderly patients. The current generation of devices is based on xenogenic leaflet material, involving limitations with regard to calcification and durability. Artificial polymeric leaflet-structures re-present a promising approach for improvement of valve performance. Within the current work, finite-element ana-lysis (FEA) design studies of polymeric leaflet structures were conducted. Design of an unpressurized and axially-symmetric trileaflet heart valve was developed based on nine parameters. Physiological pressurization in FEA was specified, based on in vitro hydrodynamic testing of a commercially available heart valve prosthesis. Hyper-elastic constitutive law for polymeric leaflet material was implemented based on experimental stress strain curves resulting from uniaxial tensile and planar shear testing. As a result of FEA, time dependent leaflet deformation of the leaflet structure was calculated. Obtained leaflet dynamics were comparable to in vitro performance of the analyzed prosthesis. As a major design parameter, the lunula angle has demonstrated crucial influence on the performance of the polymeric leaflet structures. FEA represented a useful tool for design of improved polymeric leaflet structures for minimally invasive implantable heart valve prostheses.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Assessment of heart valve performance by finite-element design studies of polymeric leaflet-structures ; volume:3 ; number:2 ; year:2017 ; pages:631-634 ; extent:4
Current directions in biomedical engineering ; 3, Heft 2 (2017), 631-634 (gesamt 4)

Urheber
Pfensig, Sylvia
Kaule, Sebastian
Sämann, Michael
Stiehm, Michael
Grabow, Niels
Schmitz, Klaus-Peter
Siewert, Stefan

DOI
10.1515/cdbme-2017-0132
URN
urn:nbn:de:101:1-2023030713044827286926
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:53 MESZ

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Beteiligte

  • Pfensig, Sylvia
  • Kaule, Sebastian
  • Sämann, Michael
  • Stiehm, Michael
  • Grabow, Niels
  • Schmitz, Klaus-Peter
  • Siewert, Stefan

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