Radical‐Mediated Hydroperfluoroalkylation of Unactivated Alkenes

Abstract: The direct hydroperfluoroalkylation of a wide range of unactivated alkenes has been achieved at room temperature with readily available iodoperfluoroalkanes using 4‐tert‐butylcatechol as a source of hydrogen atom and triethylborane. The hydrotrifluoromethylation could also be achieved under these conditions using gaseous trifluoromethyl iodide. An experimentally simple two‐step, one‐pot hydrotrifluoromethylation process using the easy‐to‐use trifluoromethanesulfonyl chloride as the source of trifluoromethyl radicals has also been developed. Using these two approaches, a broad range of substrates, including isoprenoid natural products, were efficiently derivatized.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Radical‐Mediated Hydroperfluoroalkylation of Unactivated Alkenes ; day:17 ; month:07 ; year:2023 ; extent:10 ; Advanced synthesis & catalysis ; (17.07.2023) (gesamt 10)

Contributors, Places and Time

• Creator: Sissengaliyeva, Gulsana ; Dénès, Fabrice ; Girbu, Vladilena ; Kulcitki, Veaceslav ; Hofstetter, Elena ; Renaud, Philippe

Further information

• DOI: 10.1002/adsc.202300299
• URN: urn:nbn:de:101:1-2023071715213976935456
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:47 AM CEST