A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription
Abstract: Since numerous RNAs and RBPs prevalently localize to active chromatin regions, many RNA‐binding proteins (RBPs) may be potential transcriptional regulators. RBPs are generally thought to regulate transcription via noncoding RNAs. Here, we describe a distinct, dual mechanism of transcriptional regulation by the previously uncharacterized tRNA‐modifying enzyme, hTrmt13. On one hand, hTrmt13 acts in the cytoplasm to catalyze 2'‐O‐methylation of tRNAs, thus regulating translation in a manner depending on its tRNA‐modification activity. On the other hand, nucleus‐localized hTrmt13 directly binds DNA as a transcriptional co‐activator of key epithelial–mesenchymal transition factors, thereby promoting cell migration independent of tRNA‐modification activity. These dual functions of hTrmt13 are mutually exclusive, as it can bind either DNA or tRNA through its CHHC zinc finger domain. Finally, we find that hTrmt13 expression is tightly associated with poor prognosis and survival in diverse cancer patients. Our discovery of the noncatalytic roles of an RNA‐modifying enzyme provides a new perspective for understanding epitranscriptomic regulation.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription ; day:01 ; month:12 ; year:2021 ; extent:21
The EMBO journal / European Molecular Biology Organization ; (01.12.2021) (gesamt 21)
- Creator
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Li, Hao
Dong, Han
Xu, Beisi
Xiong, Qing‐Ping
Li, Cai‐Tao
Yang, Wen‐Qing
Li, Jing
Huang, Zhi‐Xuan
Zeng, Qi‐Yu
Wang, En‐Duo
Liu, Ru‐Juan
- DOI
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10.15252/embj.2021108544
- URN
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urn:nbn:de:101:1-2021120114272392479771
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
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Associated
- Li, Hao
- Dong, Han
- Xu, Beisi
- Xiong, Qing‐Ping
- Li, Cai‐Tao
- Yang, Wen‐Qing
- Li, Jing
- Huang, Zhi‐Xuan
- Zeng, Qi‐Yu
- Wang, En‐Duo
- Liu, Ru‐Juan
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