Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
Abstract: Traditionally, biosensors are designed to detect one specific analyte. Nevertheless, disease progression is regulated in a highly interactive way by different classes of biomolecules like proteins and nucleic acids. Therefore, a more comprehensive analysis of biomarkers from a single sample is of utmost importance to further improve both, the accuracy of diagnosis as well as the therapeutic success. This review summarizes fundamentals like biorecognition and sensing strategies for the simultaneous detection of proteins and nucleic acids and discusses challenges related to multianalyte biosensor development. We present an overview of the current state of biosensors for the combined detection of protein and nucleic acid biomarkers associated with widespread diseases, among them cancer and infectious diseases. Furthermore, we outline the multianalyte analysis in the rapidly evolving field of single-cell multiomics, to stress its significance for the future discovery and validation of biomarkers. Finally, we provide a critical perspective on the performance and translation potential of multianalyte biosensors for medical diagnostics
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
ISSN: 1873-4235
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2023
- DOI
-
10.1016/j.bios.2023.115800
- URN
-
urn:nbn:de:bsz:25-freidok-2407750
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:47 PM CET
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2023
Other Objects (12)
Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
Microfluidic impedance biosensors for monitoring cancer cell behaviors
Fabrication of interdigitated electrode arrays for biosensors by advanced mask aligner lithography
Methods for rapid nucleic acid extraction and detection
Electrochemical microfluidic multiplexed biosensor platform for point-of-care testing
Utilizing the ability of electrochemical NO sensors: micro sensor designs for hypoxic cell cultures : = Designs für Mikrosensoren für hypoxische Zellkulturen unter Ausnutzung der Leistungsfähigkeit von elektrochemischen NO-Sensoren
Characterization of the adsorption of biomolecules in open electrowetting on dielectrics microfluidics-tool platform for bio-analytical applications : = Charakterisierung des Adsorptionsverhaltens von Biomolekülen auf Open Electrowetting On Dielectrics Mikrofluidikplattform für Bioanalytische Anwendungen
Multiparametric, flexible microsensors for in vivo application
Electrochemical microsensors for superoxide monitoring in cell culture : = Elektrochemische Mikrosensoren fuer Superoxid-Monitoring in Zellkultur
Electrochemical microsensor system for cell culture monitoring : = Elektrochemisches Mikrosensor-System zum Zellkultur-Monitoring
Microfluidic immunosensor for point-of-care diagnostics : = Microfluidischer Immunosensor für patientennahe Diagnostik
Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
Microfluidic impedance biosensors for monitoring cancer cell behaviors
Fabrication of interdigitated electrode arrays for biosensors by advanced mask aligner lithography
Methods for rapid nucleic acid extraction and detection
Electrochemical microfluidic multiplexed biosensor platform for point-of-care testing
Utilizing the ability of electrochemical NO sensors: micro sensor designs for hypoxic cell cultures : = Designs für Mikrosensoren für hypoxische Zellkulturen unter Ausnutzung der Leistungsfähigkeit von elektrochemischen NO-Sensoren
Characterization of the adsorption of biomolecules in open electrowetting on dielectrics microfluidics-tool platform for bio-analytical applications : = Charakterisierung des Adsorptionsverhaltens von Biomolekülen auf Open Electrowetting On Dielectrics Mikrofluidikplattform für Bioanalytische Anwendungen
Multiparametric, flexible microsensors for in vivo application
Electrochemical microsensors for superoxide monitoring in cell culture : = Elektrochemische Mikrosensoren fuer Superoxid-Monitoring in Zellkultur
Electrochemical microsensor system for cell culture monitoring : = Elektrochemisches Mikrosensor-System zum Zellkultur-Monitoring
Microfluidic immunosensor for point-of-care diagnostics : = Microfluidischer Immunosensor für patientennahe Diagnostik
Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
Microfluidic impedance biosensors for monitoring cancer cell behaviors
Fabrication of interdigitated electrode arrays for biosensors by advanced mask aligner lithography
Methods for rapid nucleic acid extraction and detection
Electrochemical microfluidic multiplexed biosensor platform for point-of-care testing
Utilizing the ability of electrochemical NO sensors: micro sensor designs for hypoxic cell cultures : = Designs für Mikrosensoren für hypoxische Zellkulturen unter Ausnutzung der Leistungsfähigkeit von elektrochemischen NO-Sensoren
Characterization of the adsorption of biomolecules in open electrowetting on dielectrics microfluidics-tool platform for bio-analytical applications : = Charakterisierung des Adsorptionsverhaltens von Biomolekülen auf Open Electrowetting On Dielectrics Mikrofluidikplattform für Bioanalytische Anwendungen
Multiparametric, flexible microsensors for in vivo application
Electrochemical microsensors for superoxide monitoring in cell culture : = Elektrochemische Mikrosensoren fuer Superoxid-Monitoring in Zellkultur
Electrochemical microsensor system for cell culture monitoring : = Elektrochemisches Mikrosensor-System zum Zellkultur-Monitoring