CXCR4-targeted theranostics in hematooncology: opportunities and challenges : = CXCR4-gerichtete Theranostics in der Hämato-Onkologie: Möglichkeiten und Herausforderungen
Abstract: C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in a multitude of cancers, including neoplasms of hematopoietic origin. This feature can be leveraged by a theranostic approach, which provides a read-out of the actual CXCR4 expression in vivo, followed by CXCR4-targeted radioligand therapy (RLT) exerting anti-cancer as well as myeloablative efficacy. In a recent meeting of hematooncology and nuclear medicine specialists, statements on the current clinical practice and future perspectives of this innovative concept were proposed and summarized in this opinion article. Experts concluded that i) CXCR4-directed [68Ga]Ga-PentixaFor PET/CT has the potential to improve imaging for patients with marginal zone lymphoma; ii) CXCR4-targeted RLT exerts anti-lymphoma efficacy and myeloablative effects in patients with advanced, treatment-refractory T-cell lymphomas; iii) prospective trials with CXCR4-based imaging and theranostics are warranted
- Weitere Titel
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CXCR4-gerichtete Theranostics in der Hämato-Onkologie: Möglichkeiten und Herausforderungen
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Nuklearmedizin. - 63, 02 (2024) , 57-61, ISSN: 2567-6407
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2024
- Urheber
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Werner, Rudolf A.
Haug, Alexander Robert
Buske, Christian
Heidegger, Simon
Illert, Anna Lena
Bassermann, Florian
Herhaus, Peter
Buck, Andreas K.
Duell, Johannes
Topp, Max S.
Kraus, Sabrina
Einsele, Hermann
Lapa, Constantin Frederik Victor
Raderer, Markus
Lenz, Georg
Habringer, Stefan
Tresckow, Bastian von
Keller, Ulrich
- DOI
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10.1055/a-2194-9965
- URN
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urn:nbn:de:bsz:25-freidok-2435013
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:55 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Werner, Rudolf A.
- Haug, Alexander Robert
- Buske, Christian
- Heidegger, Simon
- Illert, Anna Lena
- Bassermann, Florian
- Herhaus, Peter
- Buck, Andreas K.
- Duell, Johannes
- Topp, Max S.
- Kraus, Sabrina
- Einsele, Hermann
- Lapa, Constantin Frederik Victor
- Raderer, Markus
- Lenz, Georg
- Habringer, Stefan
- Tresckow, Bastian von
- Keller, Ulrich
- Universität
Entstanden
- 2024