Methyltransferases : : functions and applications
Abstract: In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
ChemBioChem. - 23, 18 (2022) , e202200212, ISSN: 1439-7633
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2024
- Urheber
-
Abdelraheem, Eman
Thair, Benjamin
Varela, Romina Fernández
Jockmann, Emely
Popadić, Désirée
Hailes, Helen C.
Ward, John M.
Iribarren, Adolfo M.
Lewkowicz, Elizabeth S.
Andexer, Jennifer Nina
Hagedoorn, Peter-Leon
Hanefeld, Ulf
- DOI
-
10.1002/cbic.202200212
- URN
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urn:nbn:de:bsz:25-freidok-2451580
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:53 MEZ
Datenpartner
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Beteiligte
- Abdelraheem, Eman
- Thair, Benjamin
- Varela, Romina Fernández
- Jockmann, Emely
- Popadić, Désirée
- Hailes, Helen C.
- Ward, John M.
- Iribarren, Adolfo M.
- Lewkowicz, Elizabeth S.
- Andexer, Jennifer Nina
- Hagedoorn, Peter-Leon
- Hanefeld, Ulf
- Universität
Entstanden
- 2024
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