Methyltransferases : : functions and applications
Abstract: In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
ChemBioChem. - 23, 18 (2022) , e202200212, ISSN: 1439-7633
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2024
- Creator
-
Abdelraheem, Eman
Thair, Benjamin
Varela, Romina Fernández
Jockmann, Emely
Popadić, Désirée
Hailes, Helen C.
Ward, John M.
Iribarren, Adolfo M.
Lewkowicz, Elizabeth S.
Andexer, Jennifer Nina
Hagedoorn, Peter-Leon
Hanefeld, Ulf
- DOI
-
10.1002/cbic.202200212
- URN
-
urn:nbn:de:bsz:25-freidok-2451580
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:53 PM CET
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Abdelraheem, Eman
- Thair, Benjamin
- Varela, Romina Fernández
- Jockmann, Emely
- Popadić, Désirée
- Hailes, Helen C.
- Ward, John M.
- Iribarren, Adolfo M.
- Lewkowicz, Elizabeth S.
- Andexer, Jennifer Nina
- Hagedoorn, Peter-Leon
- Hanefeld, Ulf
- Universität
Time of origin
- 2024
Other Objects (12)
Functions and requirements of informed consent in German law and practice
Aging Microglia - phenotypes, functions and implications for age-related neurodegenerative diseases
The rise of the modern Leviathan : : state functions and state features
Future Applications of the TIME
Elliptic functions and applications
Hyalocyte functions and immunology
The perfluoroadamantoxy aluminate as an ideal weakly coordinating anion? – synthesis and first applications
Why neurotechnologies? : : about the purposes, opportunities and limitations of neurotechnologies in clinical applications
In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases
Segmented thermoplastic polyesters, development, characterization and applications
Qualitative constraint-based reasoning: methods and applications
Peter Abelard's investigations into the meaning and functions of the speech sign 'est'
Functions and requirements of informed consent in German law and practice
Aging Microglia - phenotypes, functions and implications for age-related neurodegenerative diseases
The rise of the modern Leviathan : : state functions and state features
Future Applications of the TIME
Elliptic functions and applications
Hyalocyte functions and immunology
The perfluoroadamantoxy aluminate as an ideal weakly coordinating anion? – synthesis and first applications
Why neurotechnologies? : : about the purposes, opportunities and limitations of neurotechnologies in clinical applications
In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases
Segmented thermoplastic polyesters, development, characterization and applications
Qualitative constraint-based reasoning: methods and applications
Peter Abelard's investigations into the meaning and functions of the speech sign 'est'
Functions and requirements of informed consent in German law and practice
Aging Microglia - phenotypes, functions and implications for age-related neurodegenerative diseases
The rise of the modern Leviathan : : state functions and state features
Future Applications of the TIME
Elliptic functions and applications
Hyalocyte functions and immunology
The perfluoroadamantoxy aluminate as an ideal weakly coordinating anion? – synthesis and first applications
Why neurotechnologies? : : about the purposes, opportunities and limitations of neurotechnologies in clinical applications
In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases
Segmented thermoplastic polyesters, development, characterization and applications
Qualitative constraint-based reasoning: methods and applications