Genomics‐Driven Discovery of NO‐Donating Diazeniumdiolate Siderophores in Diverse Plant‐Associated Bacteria

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Abstract: Siderophores are key players in bacteria–host interactions, with the main function to provide soluble iron for their producers. Gramibactin from rhizosphere bacteria expands siderophore function and diversity as it delivers iron to the host plant and features an unusual diazeniumdiolate moiety for iron chelation. By mutational analysis of the grb gene cluster, we identified genes (grbD and grbE) necessary for diazeniumdiolate formation. Genome mining using a GrbD‐based network revealed a broad range of orthologous gene clusters in mainly plant‐associated Burkholderia/Paraburkholderia species. Two new types of diazeniumdiolate siderophores, megapolibactins and plantaribactin were fully characterized. In vitro assays and in vivo monitoring experiments revealed that the iron chelators also liberate nitric oxide (NO) in plant roots. This finding is important since NO donors are considered as biofertilizers that maintain iron homeostasis and increase overall plant fitness.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Genomics‐Driven Discovery of NO‐Donating Diazeniumdiolate Siderophores in Diverse Plant‐Associated Bacteria ; volume:58 ; number:37 ; year:2019 ; pages:13024-13029 ; extent:6
Angewandte Chemie / International edition. International edition ; 58, Heft 37 (2019), 13024-13029 (gesamt 6)

Creator: Hermenau, Ron
Mehl, Jule L.
Ishida, Keishi
Dose, Benjamin
Pidot, Sacha J.
Stinear, Timothy P.
Hertweck, Christian

DOI: 10.1002/anie.201906326

URN: urn:nbn:de:101:1-2022071210022718099376

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:27 AM CEST

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Hermenau, Ron
Mehl, Jule L.
Ishida, Keishi
Dose, Benjamin
Pidot, Sacha J.
Stinear, Timothy P.
Hertweck, Christian

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