Locally advanced pancreatic head cancer – margin-positive resection or bypass?
Abstract: Pancreatic cancer is a highly aggressive disease with poor survival. The only effective therapy offering long-term survival is complete surgical resection. In the setting of nonmetastatic disease, locally advanced tumors constitute a technical challenge to the surgeon and may result in margin-positive resection margins. Few studies have evaluated the implications of the latter in depth. The aim of this study was to compare the margin-positive situation to palliative bypass procedures and margin-negative resections in terms of perioperative and long-term outcome. By retrospective analysis of prospectively maintained data from 360 patients operated for pancreatic cancer at our institution, we provide evidence that margin-positive resection still yields a significant survival benefit over palliative bypass procedures. At the same time, perioperative severe morbidity and mortality are not significantly increased. Our observations suggest that pancreatic cancer should be resected whenever technically feasible, including, cases of locally advanced disease
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
ISRN Surgery. 2012 (2012), Article ID 513241, 6 pages, DOI 10.5402/2012/513241, issn: 2090-5793
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
- Schlagwort
-
Bauchspeicheldrüsenkrebs
Krebs
Onkologie
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2012
- Beteiligte Personen und Organisationen
- DOI
-
10.5402/2012/513241
- URN
-
urn:nbn:de:bsz:25-freidok-118720
- Rechteinformation
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:49 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
Entstanden
- 2012
Ähnliche Objekte (12)
Impact of resection margin status on survival in advanced N stage pancreatic cancer – a multi-institutional analysis
Extended distal pancreatectomy with en bloc resection of the celiac axis for locally advanced pancreatic cancer: a case report and review of the literature
Surgical pancreatic biopsies for cases with locally advanced pancreatic cancer with inconclusive histology after interventional biopsy
Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results
Extended resection in pancreatic metastases : feasibility, frequency, and long-term outcome
Systematic review and meta-analysis of arterial resection in pancreatic surgery
Pancreatic resection in older patients: a retrospective single-center outcome analysis
Resection of thoracic malignancies infiltrating cardiac structures with use of cardiopulmonary bypass
Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma
Patient-relevant costs for organ preservation versus radical resection in locally advanced rectal cancer
Impact of Aspirin Intake on Postoperative Survival after Primary Pancreatic Resection of Pancreatic Ductal Adenocarcinoma—A Single-Center Evaluation
Impact of Patient Age on Postoperative Short-Term and Long-Term Outcome after Pancreatic Resection of Pancreatic Ductal Adenocarcinoma
Impact of resection margin status on survival in advanced N stage pancreatic cancer – a multi-institutional analysis
Extended distal pancreatectomy with en bloc resection of the celiac axis for locally advanced pancreatic cancer: a case report and review of the literature
Surgical pancreatic biopsies for cases with locally advanced pancreatic cancer with inconclusive histology after interventional biopsy
Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results
Extended resection in pancreatic metastases : feasibility, frequency, and long-term outcome
Systematic review and meta-analysis of arterial resection in pancreatic surgery
Pancreatic resection in older patients: a retrospective single-center outcome analysis
Resection of thoracic malignancies infiltrating cardiac structures with use of cardiopulmonary bypass
Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma
Patient-relevant costs for organ preservation versus radical resection in locally advanced rectal cancer
Impact of Aspirin Intake on Postoperative Survival after Primary Pancreatic Resection of Pancreatic Ductal Adenocarcinoma—A Single-Center Evaluation
Impact of Patient Age on Postoperative Short-Term and Long-Term Outcome after Pancreatic Resection of Pancreatic Ductal Adenocarcinoma
Impact of resection margin status on survival in advanced N stage pancreatic cancer – a multi-institutional analysis
Extended distal pancreatectomy with en bloc resection of the celiac axis for locally advanced pancreatic cancer: a case report and review of the literature
Surgical pancreatic biopsies for cases with locally advanced pancreatic cancer with inconclusive histology after interventional biopsy
Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results
Extended resection in pancreatic metastases : feasibility, frequency, and long-term outcome
Systematic review and meta-analysis of arterial resection in pancreatic surgery
Pancreatic resection in older patients: a retrospective single-center outcome analysis
Resection of thoracic malignancies infiltrating cardiac structures with use of cardiopulmonary bypass
Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma
Patient-relevant costs for organ preservation versus radical resection in locally advanced rectal cancer
Impact of Aspirin Intake on Postoperative Survival after Primary Pancreatic Resection of Pancreatic Ductal Adenocarcinoma—A Single-Center Evaluation