An infectious bat-derived chimeric influenza virus harbouring the entry machinery of an influenza A virus

Abstract: In 2012, the complete genomic sequence of a new and potentially harmful influenza A-like virus from bats (H17N10) was identified. However, infectious influenza virus was neither isolated from infected bats nor reconstituted, impeding further characterization of this virus. Here we show the generation of an infectious chimeric virus containing six out of the eight bat virus genes, with the remaining two genes encoding the haemagglutinin and neuraminidase proteins of a prototypic influenza A virus. This engineered virus replicates well in a broad range of mammalian cell cultures, human primary airway epithelial cells and mice, but poorly in avian cells and chicken embryos without further adaptation. Importantly, the bat chimeric virus is unable to reassort with other influenza A viruses. Although our data do not exclude the possibility of zoonotic transmission of bat influenza viruses into the human population, they indicate that multiple barriers exist that makes this an unlikely event

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Nature communications. 5 (2014), article number 4448, doi 10.1038/ncomms5448, issn: 2041-1723 ; IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs

Klassifikation und Themen

• Schlagwort: Grippe ; Viruskrankheit

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Albert-Ludwigs-Universität Freiburg
• (wann): 2014
• Urheber: Juozapaitis, Mindaugas ; Moreira, Étori ; Mena, Ignacio ; Giese, Sebastian ; Riegger, David Martin ; Schwemmle, Martin
• Beteiligte Personen und Organisationen: Albert-Ludwigs-Universität Freiburg ; Universitätsklinikum Freiburg ; Institut für Virologie

Weitere Informationen

• DOI: 10.1038/ncomms5448
• URN: urn:nbn:de:bsz:25-freidok-118198
• Rechteinformation: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 25.03.2025, 13:52 MEZ