Building of AMPA‐type glutamate receptors in the endoplasmic reticulum and its implication for excitatory neurotransmission
Abstract: AMPA‐type glutamate receptors (AMPARs), the key elements of fast excitatory neurotransmission in the brain, are receptor ion channels whose core is assembled from pore‐forming and three distinct types of auxiliary subunits. While it is well established that this assembly occurs in the endoplasmic reticulum (ER), it has remained largely enigmatic how this receptor‐building happens. Here we review recent findings on the biogenesis of AMPARs in native neurons as a multistep production line that is defined and operated by distinct ER‐resident helper proteins, and we discuss how impairment of these operators by mutations or targeted gene‐inactivation leads to severe phenotypes in both humans and rodents. We suggest that the recent data on AMPAR biogenesis provide new insights into a process that is key to the formation and operation of excitatory synapses and their activity‐dependent dynamics, as well as for the operation of the mammalian brain under normal and pathological conditions
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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The journal of physiology / The Physiological Society. - 599, 10 (2021) , 2639-2653, ISSN: 1469-7793
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
- DOI
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10.1113/jp279025
- URN
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urn:nbn:de:bsz:25-freidok-1748249
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:02 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Schwenk, Jochen
- Fakler, Bernd
- Universität
Entstanden
- 2021
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