NHC Catalysis for Umpolung Pyridinium Alkylation via Deoxy‐Breslow Intermediates
Abstract: Umpolung N‐heterocyclic carbene (NHC) catalysis of non‐aldehyde substrates offers new pathways for C−C bond formation, but has proven challenging to develop in terms of viable substrate classes. Here, we demonstrate that pyridinium ions can undergo NHC addition and subsequent intramolecular C−C bond formation through a deoxy‐Breslow intermediate. The alkylation demonstrates, for the first time, that deoxy‐Breslow intermediates are viable for catalytic umpolung of areniums.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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NHC Catalysis for Umpolung Pyridinium Alkylation via Deoxy‐Breslow Intermediates ; day:18 ; month:02 ; year:2022 ; extent:1
Angewandte Chemie ; (18.02.2022) (gesamt 1)
- Urheber
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Wu, Terence
Tatton, Matthew R.
Greaney, Michael F.
- DOI
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10.1002/ange.202117524
- URN
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urn:nbn:de:101:1-2022021814125700470909
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:30 MESZ
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Beteiligte
- Wu, Terence
- Tatton, Matthew R.
- Greaney, Michael F.
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