Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C
Abstract: This study investigated the effect of combined thymosin α1 and vitamin C (Tα1 + VitC) on the immunological responses of septic rats. Five groups were designed. The septic model was established by the cecal ligation puncture (CLP) method. The sham group did not undergo CLP, the model group was given normal saline solution, the Tα1 group was given Tα1 (200 µg/kg), the VitC group was given VitC (200 mg/kg), and the Tα1 + VitC group was given Tα1 + VitC. Specimens for immunological analyses were collected at 6, 12, 24, and 48 h posttreatment in each group except for the sham group (only at 48 h). CD4 + CD25 + T cells in the peripheral blood and dendritic cell (DC) proportions in the spleen were analyzed by flow cytometry. Tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), transforming growth factor-β (TGF-ß1), and nuclear factor kappa-B (NF-κB) were measured by ELISA. CD4 + CD25 + T cells and OX62 + DCs levels significantly increased in the model group and decreased in the Tα1 and/or VitC treatment groups. Similarly, the levels of TNF-α, IL-6, TGF-ß1, and NF-κB significantly increased in the model group and decreased in the Tα1, VitC, and Tα1 + VitC groups, indicating that combined Tα1 and VitC therapy may help regulate the immunological state of patients with sepsis, thereby improving prognosis.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C ; volume:18 ; number:1 ; year:2023 ; extent:13
Open life sciences ; 18, Heft 1 (2023) (gesamt 13)
- Urheber
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Zhang, Daquan
Wang, Lu
Wang, Zhigao
Shi, Xiaohui
Tang, Wen
Jiang, Long
Bo Ran Yi, Ba Yin Cha Han
Lv, Xinwei
Hu, Congyu
Xiao, Dong
- DOI
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10.1515/biol-2022-0551
- URN
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urn:nbn:de:101:1-2023020713084220859941
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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05.08.2025, 11:52 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhang, Daquan
- Wang, Lu
- Wang, Zhigao
- Shi, Xiaohui
- Tang, Wen
- Jiang, Long
- Bo Ran Yi, Ba Yin Cha Han
- Lv, Xinwei
- Hu, Congyu
- Xiao, Dong
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