Epigenetic Regulation during Primordial Germ Cell Development and Differentiation

Germline development varies significantly across metazoans. However, mammalian primordial germ cell (PGC) development has key conserved landmarks, including a critical period of epigenetic reprogramming that precedes sex-specific differentiation and gametogenesis. Epigenetic alterations in the germline are of unique importance due to their potential to impact the next generation. Therefore, regulation of, and by, the non-coding genome is of utmost importance during these epigenomic events. Here, we detail the key chromatin changes that occur during mammalian PGC development and how these interact with the expression of non-coding RNAs alongside broader epitranscriptomic changes. We identify gaps in our current knowledge, in particular regarding epigenetic regulation in the human germline, and we highlight important areas of future research.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Epigenetic Regulation during Primordial Germ Cell Development and Differentiation ; volume:15 ; number:5-6 ; year:2021 ; pages:411-431 ; extent:21 ; Sexual development ; 15, Heft 5-6 (2021), 411-431 (gesamt 21)

Contributors, Places and Time

• Creator: Ramakrishna, Navin B. ; Murison, Keir ; Miska, Eric ; Leitch, Harry G.

Further information

• DOI: 10.1159/000520412
• URN: urn:nbn:de:101:1-2021122223143264854344
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:26 AM CEST