Urine 6-bromotryptophan: associations with genetic variants and incident end-stage kidney disease
Abstract: Higher serum 6-bromotryptophan has been associated with lower risk of chronic kidney disease (CKD) progression, implicating mechanisms beyond renal clearance. We studied genetic determinants of urine 6-bromotryptophan and its association with CKD risk factors and incident end-stage kidney disease (ESKD) in 4,843 participants of the German Chronic Kidney Disease (GCKD) study. 6-bromotryptophan was measured from urine samples using mass spectrometry. Patients with higher levels of urine 6-bromotryptophan had higher baseline estimated glomerular filtration rate (eGFR, p < 0.001). A genome-wide association study of urine 6-bromotryptophan identified two significant loci possibly related to its tubular reabsorption, SLC6A19, and its production, ERO1A, which was also associated with serum 6-bromotryptophan in an independent study. The association between urine 6-bromotryptophan and time to ESKD was assessed using Cox regression. There were 216 ESKD events after four years of follow-up. Compared with patients with undetectable levels, higher 6-bromotryptophan levels were associated with lower risk of ESKD in models unadjusted and adjusted for ESKD risk factors other than eGFR (
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Scientific reports. - 10, 1 (2020) , 10018, ISSN: 2045-2322
- Schlagwort
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Biomarker
Epidemiologie
Nierenkrankheit
Risikofaktor
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2020
- Urheber
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Sekula, Peggy
Tin, Adrienne
Schultheiß, Ulla Teresa
Baid-Agrawal, Seema
Mohney, Robert P.
Steinbrenner, Inga
Yu, Bing
Luo, Shengyuan
Boerwinkle, Eric
Eckardt, Kai-Uwe
Coresh, Josef
Grams, Morgan E.
Köttgen, Anna
- DOI
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10.1038/s41598-020-66334-w
- URN
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urn:nbn:de:bsz:25-freidok-1662053
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:48 MEZ
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Beteiligte
- Sekula, Peggy
- Tin, Adrienne
- Schultheiß, Ulla Teresa
- Baid-Agrawal, Seema
- Mohney, Robert P.
- Steinbrenner, Inga
- Yu, Bing
- Luo, Shengyuan
- Boerwinkle, Eric
- Eckardt, Kai-Uwe
- Coresh, Josef
- Grams, Morgan E.
- Köttgen, Anna
- Universität
Entstanden
- 2020