Urine 6-bromotryptophan: associations with genetic variants and incident end-stage kidney disease

Abstract: Higher serum 6-bromotryptophan has been associated with lower risk of chronic kidney disease (CKD) progression, implicating mechanisms beyond renal clearance. We studied genetic determinants of urine 6-bromotryptophan and its association with CKD risk factors and incident end-stage kidney disease (ESKD) in 4,843 participants of the German Chronic Kidney Disease (GCKD) study. 6-bromotryptophan was measured from urine samples using mass spectrometry. Patients with higher levels of urine 6-bromotryptophan had higher baseline estimated glomerular filtration rate (eGFR, p < 0.001). A genome-wide association study of urine 6-bromotryptophan identified two significant loci possibly related to its tubular reabsorption, SLC6A19, and its production, ERO1A, which was also associated with serum 6-bromotryptophan in an independent study. The association between urine 6-bromotryptophan and time to ESKD was assessed using Cox regression. There were 216 ESKD events after four years of follow-up. Compared with patients with undetectable levels, higher 6-bromotryptophan levels were associated with lower risk of ESKD in models unadjusted and adjusted for ESKD risk factors other than eGFR (

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Scientific reports. - 10, 1 (2020) , 10018, ISSN: 2045-2322

Classification and Topics

• Keyword: Biomarker ; Epidemiologie ; Nierenkrankheit ; Risikofaktor

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2020
• Creator: Sekula, Peggy ; Tin, Adrienne ; Schultheiß, Ulla Teresa ; Baid-Agrawal, Seema ; Mohney, Robert P. ; Steinbrenner, Inga ; Yu, Bing ; Luo, Shengyuan ; Boerwinkle, Eric ; Eckardt, Kai-Uwe ; Coresh, Josef ; Grams, Morgan E. ; Köttgen, Anna

Further information

• DOI: 10.1038/s41598-020-66334-w
• URN: urn:nbn:de:bsz:25-freidok-1662053
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:48 PM CET