Histone Modifications in Acute Kidney Injury
Background: Acute kidney injury (AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial. In recent years, epigenetics has emerged as an important regulatory mechanism in AKI. Summary: There are several types of histone modification, including methylation, acetylation, phosphorylation, crotonylation, citrullination, and sumoylation. Histone modifications are associated with the transcription of many genes and activation of multiple signaling pathways that contribute to the pathogenesis of AKI. Thus, targeting histone modification may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery. In this review, we summarize recent advances on the modification, regulation, and implication of histone modifications in AKI. Key Messages: Histone modifications contribute to the pathogenesis of AKI. Understanding of epigenetic regulation in AKI will aid in establishing the utility of pharmacologic targeting of histone modification as a potential novel therapy for AKI.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Histone Modifications in Acute Kidney Injury ; volume:8 ; number:6 ; year:2022 ; pages:466-477 ; extent:12
Kidney diseases ; 8, Heft 6 (2022), 466-477 (gesamt 12)
- Creator
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Wang, Jun
Shen, Fengchen
Liu, Feng
Zhuang, Shougang
- DOI
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10.1159/000527799
- URN
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urn:nbn:de:101:1-2022121423510694815392
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:39 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wang, Jun
- Shen, Fengchen
- Liu, Feng
- Zhuang, Shougang
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Qualitative analysis for the nonlinear fractional Hartree type system with nonlocal interaction
A note on singular integrals with angular integrability
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Endpoint regularity of discrete multisublinear fractional maximal operators associated with ℓ1 $\ell^1}$-balls
Endoscopic treatment of esophageal intramural abscess caused by embedded metal clip: a rare delayed complication of endoscopic submucosal dissection
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Retraction Note: Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy
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A note on singular integrals with angular integrability
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Endoscopic treatment of esophageal intramural abscess caused by embedded metal clip: a rare delayed complication of endoscopic submucosal dissection
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