Nanomaterial‐Boosted Tumor Immunotherapy Through Natural Killer Cells

Natural killer (NK)‐cell immunotherapy as an alternative to T‐cell immunotherapy has been widely used in clinical cell immunotherapy of various tumors. Despite the surprising findings, the widespread applications of NK cells are still limited by the insufficient expansion and short lifespan of adoptive NK cells in vivo, the poor penetration of NK cells in solid tumors, as well as the immunosuppressive tumor microenvironment that may cause the inactivation of NK cells. Fortunately, the emergence of nanomaterials provides many opportunities to address these vexing problems, thus overcoming the barriers faced by NK cells and promoting the tumor inhibitory efficacy of NK cells. Herein, the recent advances in the rational design of nanomaterials for boosting the NK cell‐based immunotherapy, mainly through enhancing NK cell engagement with tumors, boosting NK cell activation or expansion, as well as redirecting NK cells to tumor cells, are reviewed. Lastly, the design and preparation of next‐generation nanomaterials that aim to further boost the NK cell‐based immunotherapy are briefly discussed.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Nanomaterial‐Boosted Tumor Immunotherapy Through Natural Killer Cells ; day:27 ; month:10 ; year:2022 ; extent:16 ; Advanced nanoBiomed research ; (27.10.2022) (gesamt 16)

Beteiligte, Orts- und Zeitangaben

• Urheber: Zhan, Mengsi ; Guo, Yunqi ; Shen, Mingwu ; Shi, Xiangyang

Weitere Informationen

• DOI: 10.1002/anbr.202200096
• URN: urn:nbn:de:101:1-2022102815062244619395
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:26 MESZ