Patient‐Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening
Abstract: Upper tract urothelial carcinomas (UTUCs) are rare entities that are usually diagnosed at advanced stages. Research on UTUC pathobiology and clinical management has been hampered by the lack of models accurately reflecting disease nature and diversity. In this study, a modified organoid culture system is used to generate a library of 25 patient‐derived UTUC organoid lines retaining the histological architectures, marker gene expressions, genomic landscapes, and gene expression profiles of their parental tumors. The study demonstrates that the responses of UTUC organoids to anticancer drugs can be identified and the model supports the exploration of novel treatment strategies. This work proposes a modified protocol for generating patient‐derived UTUC organoid lines that may help elucidate UTUC pathophysiology and assess the responses of these diseases to various drug therapies in personalized medicine.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Patient‐Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening ; day:16 ; month:12 ; year:2021 ; extent:16
Advanced science ; (16.12.2021) (gesamt 16)
- Creator
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Li, Zhichao
Xu, Haibo
Gong, Yanqing
Chen, Wei
Zhan, Yonghao
Yu, Lei
Sun, Yangyang
Li, Aolin
He, Shiming
Guan, Bao
Wu, Yucai
Xiong, Gengyan
Fang, Dong
He, Yuhui
Tang, Qi
Yao, Lin
Hu, Zheng
Mei, Hongbing
He, Zhisong
Cai, Zhiming
Guo, Yinglu
Li, Xuesong
Zhou, Liqun
Huang, Weiren
- DOI
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10.1002/advs.202103999
- URN
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urn:nbn:de:101:1-2021121714120053360277
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:23 AM CEST
Data provider
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Associated
- Li, Zhichao
- Xu, Haibo
- Gong, Yanqing
- Chen, Wei
- Zhan, Yonghao
- Yu, Lei
- Sun, Yangyang
- Li, Aolin
- He, Shiming
- Guan, Bao
- Wu, Yucai
- Xiong, Gengyan
- Fang, Dong
- He, Yuhui
- Tang, Qi
- Yao, Lin
- Hu, Zheng
- Mei, Hongbing
- He, Zhisong
- Cai, Zhiming
- Guo, Yinglu
- Li, Xuesong
- Zhou, Liqun
- Huang, Weiren
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