Patient‐Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening
Abstract: Upper tract urothelial carcinomas (UTUCs) are rare entities that are usually diagnosed at advanced stages. Research on UTUC pathobiology and clinical management has been hampered by the lack of models accurately reflecting disease nature and diversity. In this study, a modified organoid culture system is used to generate a library of 25 patient‐derived UTUC organoid lines retaining the histological architectures, marker gene expressions, genomic landscapes, and gene expression profiles of their parental tumors. The study demonstrates that the responses of UTUC organoids to anticancer drugs can be identified and the model supports the exploration of novel treatment strategies. This work proposes a modified protocol for generating patient‐derived UTUC organoid lines that may help elucidate UTUC pathophysiology and assess the responses of these diseases to various drug therapies in personalized medicine.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Patient‐Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening ; day:16 ; month:12 ; year:2021 ; extent:16
Advanced science ; (16.12.2021) (gesamt 16)
- Urheber
-
Li, Zhichao
Xu, Haibo
Gong, Yanqing
Chen, Wei
Zhan, Yonghao
Yu, Lei
Sun, Yangyang
Li, Aolin
He, Shiming
Guan, Bao
Wu, Yucai
Xiong, Gengyan
Fang, Dong
He, Yuhui
Tang, Qi
Yao, Lin
Hu, Zheng
Mei, Hongbing
He, Zhisong
Cai, Zhiming
Guo, Yinglu
Li, Xuesong
Zhou, Liqun
Huang, Weiren
- DOI
-
10.1002/advs.202103999
- URN
-
urn:nbn:de:101:1-2021121714120053360277
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:23 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Li, Zhichao
- Xu, Haibo
- Gong, Yanqing
- Chen, Wei
- Zhan, Yonghao
- Yu, Lei
- Sun, Yangyang
- Li, Aolin
- He, Shiming
- Guan, Bao
- Wu, Yucai
- Xiong, Gengyan
- Fang, Dong
- He, Yuhui
- Tang, Qi
- Yao, Lin
- Hu, Zheng
- Mei, Hongbing
- He, Zhisong
- Cai, Zhiming
- Guo, Yinglu
- Li, Xuesong
- Zhou, Liqun
- Huang, Weiren
Ähnliche Objekte (12)
Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous
Patient-derived organoid (PDO) platforms to facilitate clinical decision making
AI-empowered game architecture and application for resource provision and scheduling in multi-clouds
The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings
Correction to: The effect of methanol fixation on single-cell RNA sequencing data
Role of periostin in ECRS
Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time
The effect of methanol fixation on single-cell RNA sequencing data
Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene
Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy
BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro
Establishment and drug screening of patient-derived extrahepatic biliary tract carcinoma organoids
Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous
Patient-derived organoid (PDO) platforms to facilitate clinical decision making
AI-empowered game architecture and application for resource provision and scheduling in multi-clouds
The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings
Correction to: The effect of methanol fixation on single-cell RNA sequencing data
Role of periostin in ECRS
Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time
The effect of methanol fixation on single-cell RNA sequencing data
Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene
Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy
BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro
Establishment and drug screening of patient-derived extrahepatic biliary tract carcinoma organoids
Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous
Patient-derived organoid (PDO) platforms to facilitate clinical decision making
AI-empowered game architecture and application for resource provision and scheduling in multi-clouds
The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings
Correction to: The effect of methanol fixation on single-cell RNA sequencing data
Role of periostin in ECRS
Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time
The effect of methanol fixation on single-cell RNA sequencing data
Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene
Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy
BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro