Improved efficacy of tafasitamab plus lenalidomide versus systemic therapies for relapsed/refractory DLBCL: RE-MIND2, an observational retrospective matched cohort study

Abstract: Purpose:
In RE-MIND2 (NCT04697160), patient-level outcomes from the L-MIND study (NCT02399085) of tafasitamab plus lenalidomide were retrospectively compared with patient-level matched observational cohorts treated with National Cancer Care Network (NCCN)/European Society for Medical Oncology (ESMO)-listed systemic therapies for relapsed/refractory diffuse large B-cell lymphoma (DLBCL).

Patients and Methods:
Data were collected from health records of eligible patients aged ≥18 years with histologically confirmed DLBCL who had received ≥2 systemic therapies for DLBCL (including ≥1 anti-CD20 therapy). Patients from L-MIND were matched with patients from the RE-MIND2 observational cohort using estimated propensity score-based 1:1 nearest-neighbor matching, balanced for nine covariates. The primary analysis compared tafasitamab plus lenalidomide with patients who received any systemic therapy for R/R DLBCL (pooled in one cohort) or bendamustine plus rituximab (BR) or rituximab plus gemcitabine and oxaliplatin (R-GemOx; as two distinct cohorts). The primary endpoint was overall survival (OS). Secondary endpoints included treatment response and time-to-event outcomes.

Results:
In RE-MIND2, 3,454 patients were enrolled from 200 sites in North America, Europe, and Asia-Pacific. Strictly matched pairs of patients consisted of tafasitamab plus lenalidomide versus systemic therapies pooled (n = 76 pairs), versus BR (n = 75 pairs), and versus R­GemOx (n = 74 pairs). Significantly prolonged OS was reported with tafasitamab plus lenalidomide versus systemic pooled therapies [hazard ratios (HR): 0.55; P = 0.0068], BR (HR: 0.42; P < 0.0001), and R-GemOx (HR: 0.47; P = 0.0003).

Conclusions:
RE-MIND2, a retrospective observational study, met its primary endpoint, demonstrating prolonged OS with tafasitamab plus lenalidomide versus BR and R-GemOx

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Clinical cancer research. - 28, 18 (2022) , 4003-4017, ISSN: 1557-3265

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2022
Urheber
Nowakowski, Grzegorz S.
Yoon, Dok Hyun
Peters, Anthea
Mondello, Patrizia
Joffe, Erel
Fleury, Isabelle
Greil, Richard
Ku, Matthew
Marks, Reinhard
Kim, Kibum
Zinzani, Pier Luigi
Trotman, Judith
Huang, Dan
Waltl, Eva E.
Winderlich, Mark Andre
Kurukulasuriya, Nuwan C.
Ambarkhane, Sumeet
Heß, Georg
Salles, Gilles

DOI
10.1158/1078-0432.CCR-21-3648
URN
urn:nbn:de:bsz:25-freidok-2285792
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:44 MEZ

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Beteiligte

  • Nowakowski, Grzegorz S.
  • Yoon, Dok Hyun
  • Peters, Anthea
  • Mondello, Patrizia
  • Joffe, Erel
  • Fleury, Isabelle
  • Greil, Richard
  • Ku, Matthew
  • Marks, Reinhard
  • Kim, Kibum
  • Zinzani, Pier Luigi
  • Trotman, Judith
  • Huang, Dan
  • Waltl, Eva E.
  • Winderlich, Mark Andre
  • Kurukulasuriya, Nuwan C.
  • Ambarkhane, Sumeet
  • Heß, Georg
  • Salles, Gilles
  • Universität

Entstanden

  • 2022

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