Fever supports CD8+ effector T cell responses by promoting mitochondrial translation

Abstract: Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8+ T cells, exposure to febrile temperature (39 °C) augmented metabolic activity and T cell effector functions, despite having a limited effect on proliferation or activation marker expression. Transcriptional profiling revealed an up-regulation of mitochondrial pathways, which was consistent with increased mass and metabolism observed in T cells exposed to 39 °C. Through in vitro and in vivo models, we determined that mitochondrial translation is integral to the enhanced metabolic activity and function of CD8+ T cells exposed to febrile temperature. Transiently exposing donor lymphocytes to 39 °C prior to infusion in a myeloid leukemia mouse model conferred enhanced therapeutic efficacy, raising the possibility that exposure of T cells to febrile temperatures could have clinical potential

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Proceedings of the National Academy of Sciences of the United States of America. - 118, 25 (2021) , e2023752118, ISSN: 1091-6490

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2023
• Creator: O’Sullivan, David ; Stanczak, Michal ; Villa, Matteo ; Uhl, Franziska ; Corrado, Mauro ; Klein Geltink, Ramon I. ; Sanin, David E. ; Apostolova, Petya ; Rana, Nisha ; Edwards-Hicks, Joy ; Grzes, Katarzyna ; Kabat, Agnieszka M. ; Kyle, Ryan L. ; Fabri, Mario ; Curtis, Jonathan D. ; Buck, Michael D. ; Patterson, Annette E. ; Regina, Annamaria ; Field, Cameron S. ; Baixauli, Francesc ; Puleston, Daniel J. ; Pearce, Edward J. ; Zeiser, Robert ; Pearce, Erika L.

Further information

• DOI: 10.1073/pnas.2023752118
• URN: urn:nbn:de:bsz:25-freidok-2192162
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:54 PM CET