Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding
Abstract: Uncontrolled bleeding from traumatic injury remains the leading cause of preventable death with loss of balance between blood clotting (coagulation) and blood clot breakdown (fibrinolysis). A major limitation of existing hemostatic agents is that they require a functioning clotting system to control the bleeding and are largely based on gauze delivery scaffolds. Herein, a novel rapid wound sealant, composed of two recombinant snake venom proteins, the procoagulant ecarin, to rapidly initiate blood clotting and the antifibrinolytic textilinin, to prevent blood clot breakdown within a synthetic thermoresponsive hydrogel scaffold is developed. In vitro, it is demonstrated that clotting is rapidly initiated with only nanomolar concentrations of venom protein and clot breakdown is effectively inhibited by textilinin. A stable clot is formed within 60 s compared to normal clot formation in 8 min. In vivo studies reveal that the snake venom hydrogel rapidly controls warfarin‐induced bleeding, reducing the bleed volume from 48% to 12% and has demonstrated immune compatibility. A new class of hemostatic agents that achieve formation of rapid and stable blood clots even in the presence of blood thinners is demonstrated here.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding ; day:09 ; month:06 ; year:2022 ; extent:12
Advanced healthcare materials ; (09.06.2022) (gesamt 12)
- Creator
-
Yegappan, Ramanathan
Lauko, Jan
Wang, Zhao
Lavin, Martin F.
Kijas, Amanda W.
Rowan, Alan E.
- DOI
-
10.1002/adhm.202200574
- URN
-
urn:nbn:de:101:1-2022061015202940574358
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Yegappan, Ramanathan
- Lauko, Jan
- Wang, Zhao
- Lavin, Martin F.
- Kijas, Amanda W.
- Rowan, Alan E.
Other Objects (12)
Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface
Higher derivative corrections to O-plane actions: NS-NS sector
Comparative effectiveness and safety of tranexamic acid plus diluted epinephrine to control blood loss during total hip arthroplasty: a meta-analysis
Bioinformatics analysis of differentially expressed genes in subchondral bone in early experimental osteoarthritis using microarray data
Direct anterior versus lateral approaches for clinical outcomes after total hip arthroplasty: a meta-analysis
Coupled thermo‐hydro‐mechanical analysis of reinforced concrete beams under the effect of frost damage and sustained load
MiR-142-5p Suppresses Tumorigenesis by Targeting PIK3CA in Non-Small Cell Lung Cancer
Antibacterial properties of snake venom components
New aspects in snake venom toxicology
Molecular regulation of tomato male reproductive development
Assessing Epstein–Barr virus in gastric cancer: clinicopathological features and prognostic implications
Prediction of springback in local bending of hull plates using an optimized backpropagation neural network
Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface
Higher derivative corrections to O-plane actions: NS-NS sector
Comparative effectiveness and safety of tranexamic acid plus diluted epinephrine to control blood loss during total hip arthroplasty: a meta-analysis
Bioinformatics analysis of differentially expressed genes in subchondral bone in early experimental osteoarthritis using microarray data
Direct anterior versus lateral approaches for clinical outcomes after total hip arthroplasty: a meta-analysis
Coupled thermo‐hydro‐mechanical analysis of reinforced concrete beams under the effect of frost damage and sustained load
MiR-142-5p Suppresses Tumorigenesis by Targeting PIK3CA in Non-Small Cell Lung Cancer
Antibacterial properties of snake venom components
New aspects in snake venom toxicology
Molecular regulation of tomato male reproductive development
Assessing Epstein–Barr virus in gastric cancer: clinicopathological features and prognostic implications
Prediction of springback in local bending of hull plates using an optimized backpropagation neural network
Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface
Higher derivative corrections to O-plane actions: NS-NS sector
Comparative effectiveness and safety of tranexamic acid plus diluted epinephrine to control blood loss during total hip arthroplasty: a meta-analysis
Bioinformatics analysis of differentially expressed genes in subchondral bone in early experimental osteoarthritis using microarray data
Direct anterior versus lateral approaches for clinical outcomes after total hip arthroplasty: a meta-analysis
Coupled thermo‐hydro‐mechanical analysis of reinforced concrete beams under the effect of frost damage and sustained load
MiR-142-5p Suppresses Tumorigenesis by Targeting PIK3CA in Non-Small Cell Lung Cancer
Antibacterial properties of snake venom components
New aspects in snake venom toxicology
Molecular regulation of tomato male reproductive development
Assessing Epstein–Barr virus in gastric cancer: clinicopathological features and prognostic implications