Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions
Abstract: HnRNPs are ubiquitously expressed RNA-binding proteins, tightly controlling posttranscriptional gene regulation. Consequently, hnRNP networks are essential for cellular homeostasis and their dysregulation is associated with cancer and other diseases. However, the physiological function of hnRNPs in non-cancerous cell systems are poorly understood. We analyzed the importance of HNRNPDL in endothelial cell functions. Knockdown of HNRNPDL led to impaired proliferation, migration and sprouting of spheroids. Transcriptome analysis identified cyclin D1 (CCND1) and tropomyosin 4 (TPM4) as targets of HNRNPDL, reflecting the phenotypic changes after knockdown. Our findings underline the importance of HNRNPDL for the homeostasis of physiological processes in endothelial cells
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Biological chemistry. - 405, 4 (2024) , 229-239, ISSN: 1437-4315
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
-
2024
- Urheber
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Fischer, Sandra E.
Lichtenthaeler, Chiara
Stepanenko, Anastasiya
Heyl, Florian
Maticzka, Daniel
Kemmerer, Katrin
Klostermann, Melina
Backofen, Rolf
Zarnack, Katharina
Weigand, Julia
- DOI
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10.1515/hsz-2023-0254
- URN
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urn:nbn:de:bsz:25-freidok-2544252
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:42 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
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Beteiligte
- Fischer, Sandra E.
- Lichtenthaeler, Chiara
- Stepanenko, Anastasiya
- Heyl, Florian
- Maticzka, Daniel
- Kemmerer, Katrin
- Klostermann, Melina
- Backofen, Rolf
- Zarnack, Katharina
- Weigand, Julia
- Universität
Entstanden
- 2024
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