Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions
Abstract: HnRNPs are ubiquitously expressed RNA-binding proteins, tightly controlling posttranscriptional gene regulation. Consequently, hnRNP networks are essential for cellular homeostasis and their dysregulation is associated with cancer and other diseases. However, the physiological function of hnRNPs in non-cancerous cell systems are poorly understood. We analyzed the importance of HNRNPDL in endothelial cell functions. Knockdown of HNRNPDL led to impaired proliferation, migration and sprouting of spheroids. Transcriptome analysis identified cyclin D1 (CCND1) and tropomyosin 4 (TPM4) as targets of HNRNPDL, reflecting the phenotypic changes after knockdown. Our findings underline the importance of HNRNPDL for the homeostasis of physiological processes in endothelial cells
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Biological chemistry. - 405, 4 (2024) , 229-239, ISSN: 1437-4315
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2024
- Creator
-
Fischer, Sandra E.
Lichtenthaeler, Chiara
Stepanenko, Anastasiya
Heyl, Florian
Maticzka, Daniel
Kemmerer, Katrin
Klostermann, Melina
Backofen, Rolf
Zarnack, Katharina
Weigand, Julia
- DOI
-
10.1515/hsz-2023-0254
- URN
-
urn:nbn:de:bsz:25-freidok-2544252
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:54 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Fischer, Sandra E.
- Lichtenthaeler, Chiara
- Stepanenko, Anastasiya
- Heyl, Florian
- Maticzka, Daniel
- Kemmerer, Katrin
- Klostermann, Melina
- Backofen, Rolf
- Zarnack, Katharina
- Weigand, Julia
- Universität
Time of origin
- 2024
Other Objects (12)
Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions
Expressivity and decidability of first-order languages over feature trees
Expressivity and decidability of first-order languages over feature trees
A complete axiomatization of a theory with feature and arity constraints
Regular path expressions in feature logic
How to win a game with features
A complete and recursive feature theory
StoatyDive: evaluation and classification of peak profiles for sequencing data
Computational analyses of post-transcriptional regulatory mechanisms : = Computergestützte Analysen von post-transkriptionellen regulatorischen Mechanismen
Computational analysis and prediction of RNA-RNA interactions : = Computergestützte Analyse und Vorhersage von RNA-RNA-Interaktionen
Using local RNA secondary structures for computational comparison and clustering of RNA molecules
INFO-RNA—a server for fast inverse RNA folding satisfying sequence constraints
Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions
Expressivity and decidability of first-order languages over feature trees
Expressivity and decidability of first-order languages over feature trees
A complete axiomatization of a theory with feature and arity constraints
Regular path expressions in feature logic
How to win a game with features
A complete and recursive feature theory
StoatyDive: evaluation and classification of peak profiles for sequencing data
Computational analyses of post-transcriptional regulatory mechanisms : = Computergestützte Analysen von post-transkriptionellen regulatorischen Mechanismen
Computational analysis and prediction of RNA-RNA interactions : = Computergestützte Analyse und Vorhersage von RNA-RNA-Interaktionen
Using local RNA secondary structures for computational comparison and clustering of RNA molecules
INFO-RNA—a server for fast inverse RNA folding satisfying sequence constraints
Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions
Expressivity and decidability of first-order languages over feature trees
Expressivity and decidability of first-order languages over feature trees
A complete axiomatization of a theory with feature and arity constraints
Regular path expressions in feature logic
How to win a game with features
A complete and recursive feature theory
StoatyDive: evaluation and classification of peak profiles for sequencing data
Computational analyses of post-transcriptional regulatory mechanisms : = Computergestützte Analysen von post-transkriptionellen regulatorischen Mechanismen
Computational analysis and prediction of RNA-RNA interactions : = Computergestützte Analyse und Vorhersage von RNA-RNA-Interaktionen
Using local RNA secondary structures for computational comparison and clustering of RNA molecules