Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance
Abstract: Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provide a first line of defence via cytolysis of dysregulated intestinal epithelial cells (IEC) and cytokine-mediated re-growth of healthy IEC. Here we show that one of the most conspicuous impacts of activated IEL on IEC is the functional upregulation of antiviral interferon (IFN)-responsive genes, mediated by the collective actions of IFNs with other cytokines. Indeed, IEL activation in vivo rapidly provoked type I/III IFN receptor-dependent upregulation of IFN-responsive genes in the villus epithelium. Consistent with this, activated IEL mediators protected cells against virus infection in vitro, and pre-activation of IEL in vivo profoundly limited norovirus infection. Hence, intraepithelial T cell activation offers an overt means to promote the innate antiviral potential of the intestinal epithelium
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Nature communications. - 6 (2015) , 7090, ISSN: 2041-1723
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2019
- Urheber
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Swamy, Mahima
Abeler-Dörner, Lucie
Chettle, James
Mahlakõiv, Tanel
Goubau, Delphine
Chakravarty, Probir
Ramsay, George
Reis e Sousa, Caetano
Stäheli, Peter
Blacklaws, Barbara A.
Heeney, Jonathan L.
Hayday, Adrian C.
- Beteiligte Personen und Organisationen
- DOI
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10.1038/ncomms8090
- URN
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urn:nbn:de:bsz:25-freidok-1251838
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:36 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Swamy, Mahima
- Abeler-Dörner, Lucie
- Chettle, James
- Mahlakõiv, Tanel
- Goubau, Delphine
- Chakravarty, Probir
- Ramsay, George
- Reis e Sousa, Caetano
- Stäheli, Peter
- Blacklaws, Barbara A.
- Heeney, Jonathan L.
- Hayday, Adrian C.
- Universitätsklinikum Freiburg. Institut für Virologie
- Universität
Entstanden
- 2019
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