Larotrectinib Response in NTRK3 Fusion-Driven Diffuse High-Grade Glioma

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High-grade glioma (HGG) and glioblastoma are the most common adult malignant brain tumors. The standard treatment consists of surgical resection followed by radiochemotherapy with temozolomide. The prognosis and the therapeutic options of these malignant brain tumors however are limited. Here, we describe a case of a patient with HGG with a previously unknown NTRK3 fusion that showed an extraordinary response to treatment with larotrectinib. This case supports regular testing for NTRK fusion proteins.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Larotrectinib Response in NTRK3 Fusion-Driven Diffuse High-Grade Glioma ; volume:107 ; number:7-8 ; year:2022 ; pages:433-438 ; extent:5
Pharmacology ; 107, Heft 7-8 (2022), 433-438 (gesamt 5)

Urheber
König, David
Hench, Jürgen
Frank, Stephan
Dima, Laura
Bratic Hench, Ivana
Läubli, Heinz

DOI
10.1159/000524399
URN
urn:nbn:de:101:1-2022071400312320802308
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:26 MESZ

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Beteiligte

  • König, David
  • Hench, Jürgen
  • Frank, Stephan
  • Dima, Laura
  • Bratic Hench, Ivana
  • Läubli, Heinz

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